PCT和NT-proBNP在脓毒血症患者生存状况预测中的应用与评价

Application and Aalue of PCT and NT-proBNP on Forecasting the Survival Condition in Patients with Sepsis

目的：探究患者降钙素原（PCT）和N端前体脑利钠肽（NT-proBNP）水平在评价脓毒血症患者生存状况的预测价值。方法：本研究于2013年6月-2015年6月期间,选择在我院治疗的脓毒血症患者81例为研究对象,根据患者纳入研究后1个月的生存状况,将所有研究对象分为存活组（55例）和死亡组（26例）。分别测定患者PCT和NT-proBNP水平,并记录患者急性生理与慢性健康状况（APACHEII）评分,通过ROC曲线探究PCT、NT-proBNP对患者生存预后评估的价值。结果：死亡组患者PCT水平及APACHEII评分均显著高于存活组,NT-pro BNP水平显著低于存活组患者（P〈0.05）;PCT与APACHEII评分存在正相关关系（r=0.311;P〈0.05）;NT-pro BNP水平与APACHEII评分存在负相关关系（r=-0.289;P〈0.05）;ROC曲线显示PCT、NT-proBNP水平预测患者生存状况的敏感性（86.23%、82.01%）及特异性（80.89%、87.39%）均较高。结论：脓毒血症患者血清PCT与NT-proBNP水平在预测患者病情严重程度及生存状况方面具有重要价值。

Objective： To explore the value of procalcitonin（PCT） and n-terminal pro-brain natriuretic peptide（NT-pro BNP） on forecasting the survival condition in patients with sepsis. Methods： 81 cases of patients with sepsis were treated in our hospital from June2013 to June 2015 were selected as research objects, who were divided into survival group（n=55） and death group（n=26） according to the survival condition one month after the research started. Detected the levels of PCT and NT-pro BNP, and recorded the acute physiology and chronic health conditions（APACHEII） score of two groups, and evaluated the value of PCT and NT-pro BNP on forecasting the survival condition in patients with sepsis through receiver operating characteristic（ROC） curve. Results： The level of PCT and APACHEII score in death group were significant higher than survival group, and the level of NT-pro BNP in death group were significant lower than survival group（P〈0.05）; The level of PCT was positively correlated with APACHEII score（r=0.311, P〈0.05）, and the level of NT-pro BNP was negatively correlated with APACHEII score（r =-0.289; P〈0.05）; ROC curves showed that the level of PCT,NT-pro BNP had high sensitivity（86.23%, 82.01%） and specificity（80.89%, 87.39%） on forecasting the survival condition in patients with sepsis. Conclusion： The level of PCT and NT-pro BNP plays an important role on forecasting the severity of illness and survival condition in patients with sepsis.