肌腱再生相关转录因子研究进展

Research Progress of Transcription Factors in Tendon Regeneration

肌腱作为骨骼和肌肉的连接往往容易受到损伤,目前对肌腱基本生物学有限的了解妨碍了肌腱修复技术的发展。最近,一系列肌腱生长相关因子被发现,其中Scleraxis(Scx)和Mohawk(Mkx)已被确定为肌腱生长和分化中的关键转录因子,Sox9和EGR1/2也被报道参与肌腱的生长。然而,目前研究尚未明确这些转录因子的生物学功能及其分子机制。本文就上述转录因子的分布与功能,及转录因子相关分子进行综述,为肌腱的修复提供生物学基础并探讨肌腱损伤治疗的未来发展方向。

Tendons that connect muscles to bone are considered to be the targets of sports injuries. The currently unsatisfactory state of tendon repair is largely attributable to the limited understanding of basic tendon biology. A number of tendon lineage-related transcription factors have recently been discovered and proved to provide clues for the better understanding of the development of tendon.Scleraxis and Mohawk have been identified as critical transcription factors in tendon＇s development and differentiation. Other transcription factors, such as Sox9 and Egr1/2 also have been reported to be involved in tendon＇s development. However, the molecular mechanisms and the application of those transcription factors have not been clearly proved. This article reviews the distribution and function of the transcription factors and factors related to them to provide a biological basis, as well as to discuss the future directions of development for the treatment of tendon repairment.