醋酸曲普瑞林治疗特发性中枢性早熟临床效果观察

Curative effect and safety of injection of triptorelin acetate in the treatment of idiopathic central precocious puberty

目的:探讨注射用醋酸曲普瑞林用于特发性中枢性早熟的治疗效果及安全性。方法:选取84例符合诊断标准且于我院进行治疗的特发性中枢性早熟患儿纳入研究,且采用随机、单盲法将其分作两组,对照组42例患儿给予醋酸甲地孕酮片,观察组42例患儿同时给予醋酸曲普瑞林,均连续治疗6个月,对其生长指标、性激素水平及不良反应情况进行比较。结果:两组患儿治疗前身高、体重、生长速度、预测身高及BA/CA比较差异均无统计学意义(P﹥0.05);而治疗后观察组患儿上述各项指标分别为(131.86±8.46)cm、(26.83±3.84)kg、(2.33±0.42)cm/半年、(161.89±2.99)cm和(1.15±0.29),与本组治疗前和对照组治疗后进行比较差异均具有统计学意义(P<0.05)。两组患儿治疗前LH、FSH和E2水平比较差异均无统计学意义(P﹥0.05),而观察组患儿治疗后上述各项指标分别为(1.89±0.43)IU/L、(2.34±0.34)IU/L、(11.29±3.02)pg/m L,与本组治疗前和对照组治疗后进行比较差异均具有统计学意义(P<0.05)。观察组未发现药物相关的不良反应,安全性较高。结论:注射用醋酸曲普瑞林用于特发性中枢性早熟疗效确切,能有降低患儿性激素水平,延缓其骨龄成熟,且不良反应少,临床应用价值高。

Objectives： To investigate the curative effect and safety of injection of triptorelin acetate in treatment of idiopathic central precocious puberty. Methods： 84 children with idiopathic central precocious puberty in our hospital were included in the study and divided into two groups randomly. According to the single blind method,42 cases in the control group were given megestrol acetate tablets,while 42 cases in the observation group were given triptorelin acetate in the meantime,for continuous treatment of 6 months. The growth index,sex hormone levels and adverse reaction of the two groups were compared. Results： The body weight,height growth rate,predicted height and BA / CA of the two groups before treatment were not significant difference（ P〈0. 05）; and after the treatment,the above indexes in the observation group were（ 131. 86 ± 8. 46） cm,（ 26. 83 ± 3. 84） kg,（ 2. 33 ± 0. 42）cm / half year,（ 161. 89 ± 2. 99） cm and（ 1. 15 ＋ 0. 29）. Compared with these before the treatment and the indexes of control groups after treatment,the differences were significant（ P〈0. 05）. LH,FSH and E2 levels in the two groups before treatment were not significantly different（ P〈0. 05）. The above indexes in the observation group after treatment were（ 1. 89 ± 0. 43） IU / L,（ 2. 34 ± 0. 34） IU / L,（ 11. 29 ± 3. 02） pg / m L. Compared with the indexes of the observation group before treatment and the indexes of control group after treatment,the differences were statistically significant（ P〈0. 05）. There was no drug related adverse reaction in the observation group,which was of high security. Conclusion： The injection of triptorelin acetate for idiopathic central precocious puberty in children has a definite curative effect,which can reduce the level of sex hormone,delay the maturation of bone age,with less adverse reaction,and a high clinical application value.