摘要
目的:比较评价阴茎皮片/口腔黏膜移植物尿道成形术治疗尿道狭窄优劣。方法:利用数据库Medline,EMbase,Cochrane library,Web of Science,Scopus和中国生物医学文献数据库,检索关于阴茎皮片/口腔黏膜移植物尿道成形术治疗尿道狭窄临床研究文章,提取资料,应用State12.0进行Meta分析。结果:纳入10个非随机对照研究和1个随机对照试验,共699人。唯一的随机对照试验显示,口腔黏膜组与阴茎皮片组成功率差别无统计学意义(90.5%vs 87.5%,P=0.07)。非随机对照研究Meta分析表明,口腔黏膜组优于阴茎皮片组(RR=0.86,95%CI 0.77-0.96,P=0.008)。按手术方式亚组分析表明,采用背侧镶嵌尿道成形术,口腔黏膜与阴茎皮片效果相当(RR=0.90,95%CI:0.77-1.06)。结论:阴茎皮片移植物与口腔黏膜游离移植物在前尿道狭窄一期背侧镶嵌成形术中效果相当,皆可选择。但此结论仍需大样本随机对照试验进一步证实。
Objectives： To compare and assess the efficacy of penile skin graft（ PSG） /buccal mucosa graft（ BMG） urethroplasty in the treatment of urethral stricture. Methods： Related papers on the use of PSG/BMG urethroplasty in the reconstruction of urethral defect associated with urethral stricture were searched via Medline,EMbase,Cochrane library,Web of Science,Scopus and CBMDISC. The data extracted from eligible studies were pooled using Stata 12. 0 software. Results： A total of 11 studies,including 10 non- randomized studies and a randomized controlled trial,involving 699 patients,were included. The randomized controlled trial demonstrated that success rate of BMG was 90. 5% versus 87. 5% of PSG（ P = 0. 07）. Meta- analysis of non- randomized studies showed overall success rate of urethroplasty with BMG was better than PSG（ RR = 0. 86,95% CI 0. 77- 0. 96,P =0. 008）. Subgroup analysis by surgery indicated dorsal- onlay urethroplasty with PSG or BMG had a similar overall success rate（ RR = 0. 90,95% CI： 0. 77- 1. 06）. Conclusion： One- stage dorsal- onlay urethroplasty with PSG or BMG has a comparable success rate in the treatment of anterior urethral stricture. Additional high- quality and large- scale randomized controlled trials are warranted to further validate these conclusions.
出处
《中国性科学》
2015年第10期30-34,共5页
Chinese Journal of Human Sexuality
