重组白介素-2联合微米光治疗妊娠期尖锐湿疣的疗效观察与安全性分析

Curative effect observation and safety analysis of recombinant interleukin- 2 joint micron light therapy on genital warts during pregnancy

目的:探究与分析重组白介素-2联合微米光治疗妊娠期尖锐湿疣的临床疗效与安全性。方法:选取我院自2012年10月至2014年10月收治的妊娠期尖锐湿疣患者120例,采取随机数字表法分为对照组与观察组,每组各60例,对照组给予单纯微米光治疗,观察组在单纯微米光将疣体气化的基础上对其基底部注射重组白介素-2治疗,每5d 1次,以10次为1个疗程。观察两组患者的痊愈率及复发率。结果:对照组痊愈43例,痊愈率为71.67%,观察组痊愈53例,痊愈率为88.33%,两组痊愈率相比具有显著差异(χ2=4.24,P<0.05)。对照组复发17例,复发率为28.33%,观察组复发7例,复发率为11.67%,两组复发率相比具有显著差异(χ2=4.49,P<0.05)。对照组未出现1例不良反应,观察组在进行局部封闭治疗后仅出现7例患部轻度红肿的情况,占11.67%,但胀痛未给予特殊处理,在治疗结束后2天内自行缓解,随后继续使用药物治疗。结论:采用重组白介素-2联合微米光治疗妊娠期合并尖锐湿疣的临床疗效显著,无明显不良反应,安全性较高,值得推广。

Objectives： To analyze the curative effect and safety of recombinant interleukin- 2 joint micron light therapy on genital warts during pregnancy. Methods： 120 patients with genital warts during pregnancy in our hospital from October 2012 to October 2014 were selected. According to random number table method,they were divided into control group and observation group,60 cases in each group. Control group was given pure micron light therapy on the basis of pure micron light therapy,while observation group received injection treatment of recombinant interleukin- 2,once every 5 days,10 times as a course of treatment. The healing rate and the recurrence rate of the two groups were observed. Results： There were 43 cured patients in control group and the cured rate was 71. 67%. There were 53 cured patients in observation group and the cured rate was 88. 33%. The difference in recovery rate between the two groups was significant（ chi- square = 4. 24,P〈0. 05）. There were 17 cases of recurrence in control group and the recurrence rate was 28. 33%. There were 7 cases of recurrence in observation group and the recurrence rate was 11. 67%. The difference in recurrence rate between the two groups was significant（ chi- square = 4. 49,P〈0. 05）. Conclusion： The recombinant interleukin- 2 joint micron light treatment of condyloma acuminatum during pregnancy has distinct curative effect with no obvious adverse reaction and high security,which is worth promoting.