急性心肌梗死患者半乳凝素-3血清水平变化及其相关性研究

The change and correlation study of serum galectin-3 in patients with acute myocardial infarction

目的 探讨心肌梗死患者急性期半乳凝素-3（Gal-3）的血清水平动态变化,以及与急性心肌梗死患者前脑钠肽（proBNP）、高敏C反应蛋白（hs-CRP）及冠脉病变程度的相关性.方法 选择急性心肌梗死（AMI组）患者52例及健康体检者（对照组）31例,采用酶联免疫吸附法测定AMI组发病24 h内、第3天、第7天的血清Gal-3,以及发病24h内的proBNP、hs-CRP水平,记录冠脉病变程度.结果 AMI组24 h内、第3天、第7天Gal-3水平分别为（12.58±1.98）ng/ml、（11.26±1.64）ng/ml、（9.61±1.02）ng/ml,均较正常对照组（4.64±1.34）ng/ml、（4.58±1.36）ng/ml、（4.69±1.41）ng/ml明显升高（P＜0.01）;且AMI组Gal-3水平24h内高于第3天,第3天高于第7天（P均＜0.01）;同时AMI组24 h内Gal-3、proBNP、hs-CRP水平分别为（12.58±1.98）ng/ml、（763.40±232.32）pg/ml、（6.50±0.91） μmol/L,均比对照组（4.64±1.34）ng/ml、（147.45±61.43）pg/ml、（2.26±0.93）μmol/L明显升高（P均＜0.01）.Gal-3与proBNP、hs-CRP水平呈正相关（r=0.525,r=0.492,P均＜0.01）.Gal-3、proBNP与冠状动脉病变支数、冠状动脉Gensini评分呈正相关（r=0.359,r=0.479,P均＜0.01）.结论 AMI患者血清Gal-3水平明显升高,并在发病24h内升高最明显.Gal-3与proBNP、hs-CRP水平及冠状动脉病变程度间存在相关性.

Objective To observe the change of serum galectin-3 （Gal-3） levels in patients with acute myocardial infarction （AMI） and to explore the correlation between galectin-3 and pro-brain natriuretic pep （proBNP）, high-sensitivity C-reactive protein （hs-CRP）, coronary artery disease severity. Methods Fifty-two AMI patients （AMI group） and thirty-one healthy subjects （control group） were enrolled. Enzyme linked immunosorbent assay were used to measure the serum Gal-3 levels of AMI within 24 h, third day, seventh day and serum proBNP, hs-CRP level of AMI within 24 h, and the coronary artery disease severity were record. Results In AMI group within 24 hours, the 3rd day and the 7th day, the level of Gal-3 were （12.58±1.98）ng/ ml, （11.26±1.64）ng/ml and （9.61±1.02）ng/ml, compared with the normal control group （4.64 ±1.34）ng/ml, （4.58±1.36）ng/ml, （4.69±1.41）ng/ml, there were increased significantly （P〈0.01）, and in AMI group Gal-3 levels were higher within 24 hours than the 3rd day, the 3rd day longer than 7th day （P〈0.01）, and in AMI group within 24 h of Gal-3, proBNP, hs CRP levels were （12.58±1.98）ng/ml, （763.40±232.32）pg/ml, （6.50± 0.91 ）μmol/L, which increased more significantly than those of the control group （4.64±1.34）ng/ml, （147.45± 61.43）pg/ml, （2.26±0.93）μmol/L （P〈0.01）. Serum Gal-3 level in AMI group was much higher than that in healthy control group （P〈0.01）, Serum Gal-3 level of AMI within 24 h was higher than that of third day, serum Gal-3 level of third day was higher than that of seventh day （all P〈0.01 ）, and Gal-3 was positively correlated with proBNP, hs-CRP （r=0.525, r=0.492, P〈0.01）, serum Gal-3, proBNP and hs-CRP levels in AMI group were much higher than that in healthy control group （all P〈0.01 ）, and Gal-3, proBNP were positively correlated with coronary artery lesions counts and Gensini score（r=0.359, r=0.479, all P〈0.05）. Conchmion Serum Gal-3 level in AMI group is high and keep increasing within 24 h. Ga1-3 is correlate with pruBNP, hs-CRP and coronary artery disease severity.