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内皮型一氧化氮合酶G894T基因多态性与亚洲人群糖尿病肾病相关性研究的Meta分析

The study between Nitric oxide synthase3 G894T polymorphism and diabetic nephropathy suscep- tibility in Asian
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摘要 目的探讨内皮型一氧化氮合酶（NOS3或eNOS）G984T基因多态性与亚洲人群糖尿病肾病易感性的关系。方法检索PubMed、EMBASE、中国生物医学文献数据库、中国期刊全文数据库已发表的关于NOS3G984T基因多态性与亚洲人群糖尿病易感性的符合纳入标准的文献，应用Meta分析软件对各研究综合分析此基因在亚洲人群中同糖尿病肾病关系。结果共9篇文献纳入本研究，病例组合计808例；对照组合计928例。Meta分析结果显示，TT与GG基因型相对危险度（RR）=1．98,95％可信区间（C1）1．15～3．40，P〈0．01；TG与GG基因型：RR=2．05，95％C1：1．63～2．58，P〈0．01；TT／TG与GG基因型：RR=2．08，95％CI：1．67～2．60，P〈0．01；TT与TG／GG基因型：RR：1．74，95％CI：1．04～2．92，P〈0．05；T与G等位基因：RR=1．81，95％CI：1．51～2．17，P〈0．01。结论NOS3 G984T基因多态性与亚洲人群糖尿病肾病有明显易感性。 Objective To investigate the association between polymorphism of Nitric oxide syn- thase3 （ NOS3 ） G894T and -diabetic nephropathy in Asian. Methods Studies on NOS3 G894T and- dia- betic nephropathy in Asian were screened by PubMed, EMBSE, CBM, CNKI. RR and 95% CI were calcu- lated to evaluated the association-between polymorphism of NOS3 G894T and diabetic nephropathy in Asi- an. Results 9 studies with 808 cases and 928 controls were included. The significant association of this polymorphism with diabetic nephropathy in Asian was found（ TT vs GG：RR = 1.98,95 % C1：1.15-3.40, P 〈0.01 ;TG vs GG：RR =2.05,95% CI： 1.63-2.58 ,P 〈0.01 ; TT/TG vs GG：RR = 2.08,95% CI： 1.67- 2.60 ,P 〈0.01 ;Tr vs TG/GG：RR = 1.74,95% CI： 1.04-2.92,P 〈 0.05 ;T vs G：RR = 1.81,95% CI： 1.51-2.17 ,P 〈 0.01 ）. Conclusion There was a significant association between NOS3 G894T and dia- betic nephropathy in Asian.
作者 谢志海 孙静锋 郭静生
机构地区 广东省佛山市南海高新区人民医院 中国人民解放军第 南京中医药大学附属中西医结合医院
出处 《临床内科杂志》 CAS 2015年第10期675-678,共4页 Journal of Clinical Internal Medicine
关键词 内皮型一氧化氮合酶 G984T基因 基因多态性 糖尿病肾病 META分析 Nitric oxide synthase3 G984T Polymorphism Diabetic nephropathy Metaanalysis
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献18

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2015年 第10期

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