血清淀粉样蛋白A水平与帕金森病性痴呆认知障碍的相关性研究

Correlation study between the level of serum amyloid protein A and the degree of cognitive deficits in Parklnson disease dementia patients

目的探讨血清淀粉样蛋白A（SSA）与帕金森病性痴呆（PDD）认知障碍的相关性。方法按照诊断标准选择PDD患者49例和非帕金森病患者30例，采用酶联免疫吸附试验（ELISA）检测血清中SSA水平，采用蒙特刊尔认知评估量表评估患者的认知功能。结果PDD患者不同运动功能障碍和日常生活能力受损程度的SSA水平分别是：Ⅰ级为（7．42±0．74）mg／L，Ⅱ级为（8．94±0．24）mg／L，Ⅲ级为（10．12±0．79）mg／L，Ⅳ级为（11．74±0．82）mg／L，Ⅴ级为（15．16±1．06）mg／L，相关性分析结果显示PDD患者SSA水平与运动功能障碍和日常生活能力受损程度之间呈正相关（r2=0．619，P〈0．05），SSA水平与PDD患者认知功能障碍程度之间亦呈明显正相关（r2=0．580，P〈0．05）。结论SSA可作为评判PDD患者病情严重程度的重要血清标志物。

OBjeetive To explore the correlation between the level of serum amyloid protein A （SSA） and the degree of cognitive deficits in Parkinson disease dementia（PDD） patients. Methods The 49 cases of patients with PDD and 30 eases of non Parkinson disease normal controls were chose to study strictly according to the diagnostics criterion. The SSA level was assayed by enzyme-linked immunosorbent assay（ ELISA ） technique and the cognition was scaled by Montreal Cognitive Assessment （MoCA）. Results The SSA level in different deficits degrees of the motor function and daily life were （7.42 ± 0.74） mg/L, （8.94 ± 0.24） mg/L, （ 10. 12 ± 0.79） mg/L, （ 11.74 ± 0. 82） mg/L, （ 15. 16 ± 1.06） mg/L respectively in grade Ⅰ , Ⅱ, Ⅲ Ⅳ and Ⅴ. The correlation analysis showed that the SSA level had a markedly positive correlation with the deficits degrees of the motor function and daily life in PDD patients （r2 = 0. 619 ,P 〈 0. 05 ）. Moreover, there was significantly positive correlation between the SSA level and the cognitive deficits in PDD patients （ r2 = 0. 580, P 〈 0. 05 ）. Conclusion SSA is probably as an important marker for judging the severity of PDD to supply the diagnosis and therapeutics evidences.