保妇康栓联合聚甲酚磺醛治疗宫颈糜烂的疗效观察

Effect of Baofukang suppository and policresulen in the treatment of cervical erosion

目的：探讨保妇康栓联合聚甲酚磺醛治疗宫颈糜烂的临床疗效，并观察和分析其安全性，为临床治疗提供依据。方法选择宫颈糜烂患者268例，根据入院编号随机分为对照组和观察组，两组各134例，对照组在常规治疗基础上应用保妇康栓治疗；观察组应用保妇康栓及聚甲酚磺醛治疗。评估两组患者治疗效果、创面愈合时间，症状或体征改善状况，并观察两组患者阴道不良反应。结果观察组总有效率为88．81％（119／134），高于对照组的79．85％（107／134），差异有统计学意义（χ2＝9．87，P ＜0．05）；观察组患者创面愈合时间为（23．31±177;1．78）d，短于对照组的（27．58±177;1．96）d，差异有统计学意义（t ＝11．20，P ＜0．05）；观察组治疗后腰骶部酸痛、白带量多和脓性分泌物分别为9．70％（13／134）、5．94％（8／134）和3．73％（13／134），均低于对照组治疗后的14．93％（20／134）、12．69％（17／134）和11．94％（16／134），且两组治疗后均低于治疗前，差异有统计学意义（χ2＝9．96、9．81、10．12，均 P ＜0．05）；观察组和对照组治疗后接触性出血为分别为0．00％（0／134）和1．49％（2／134），均低于治疗前，差异有统计学意义（χ2＝11．30、10．06，均 P ＜0．05）；观察组阴道不良反应率为17．16％（23／134），对照组为17．91％（24／134），两组差异无统计学意义（P ＞0．05）。结论保妇康栓及聚甲酚磺醛治疗宫颈糜烂具有较好的临床疗效，能够缩短创面愈合时间，显著降低患者的症状或体征，并具有较高的安全性。

Objective To explore the clinical efficacy of Baofukang suppository and policresulen in the treat-ment of cervical erosion,and to observe and analyze the safety,thus to provide the basis for clinical treatment.Methods 268 patients with cervical erosion were selected,they were randomly divided into the control group and the observation group,134 cases in each group.The control group was treated with Baofukang suppository on the basis of conventional treatment.The observation group received Baofukang suppository and policresulen treatment.To assess the treatment effect of the two groups,and the wound healing time,improvement of the symptoms or signs and the vaginal adverse reactions were observed.Results The total effective rate of the observation group was 88.81% （119 /134）,which was higher than that of the control group 79.85% （107 /134）,the difference was statistically significant （χ2 =9.87, P ＆lt;0.05）.The wound healing time of the observation group was （23.31 ±177;1.78）d,which was shorter than that of the control group （27.58 ±177;1.96）d,the difference was statistically significant （t =11.20,P ＆lt;0.05）.The incidence rates of lumbosacral pain,leucorrhea and purulent secretions of the observation group after treatment were 9.70%（13 /134）,5.94% （8 /134）and 3.73% （13 /134）,which were lower than those in the control group after treatment [14.93%（20 /134）,12.69% （17 /134）and 11.94% （16 /134）],and after treatment two groups were lower than those before treatment,there were statistically significant differences （χ2 =9.96,9.81,10.12,all P ＆lt;0.05）.After treatment,the contact bleeding of the observation group and the control group were 0.00% （0 /134）and 1.49%（2 /134）,which were lower than those before treatment,the differences were statistically significant （χ2 =11.30,10.06, all P ＆lt;0.05）.The incidence rate of vagina adverse reaction of the observation groups was 17.16% （23 /134）,that of the control group was 17.91% （24 /134）,there was no statistically significant difference （P ＆gt;0.05）.Conclusion Baofukang suppository combined with policresulen has better clinical curative effect in the treatment of cervical ero-sion,which can shorten the wound healing time,reduce symptoms or signs of patients,and has high security.