甲状腺功能亢进症患者血浆生长激素释放肽水平的变化及其影响因素分析

Changes of plasma growth hormone releasing peptide level and its influencing factors in patients with hyperthyroidism

目的：探讨甲状腺功能亢进症患者血浆生长激素释放肽（Ghrelin）水平的变化及其影响因素。方法选择55例甲状腺功能亢进症患者作为观察组，同期55例健康体检者作为对照组，采用酶联免疫法对及甲状腺功能亢进症患者治疗前后的血浆进行测定，比较两组患者及甲状腺功能亢进症患者治疗前后体脂百分比、Ghrelin、S-TSH 及 FT3、FT4的水平，并分析 FT3、FT4、体脂百分比及 S-TSH 与血浆 Ghrelin 的关系。结果与对照组相比，观察组患者体脂百分比及 Ghrelin 与 S-TSH 的水平均较低，而 FT3、FT4水平较高，两组比较差异有统计学意义（t1＝5．021，t2＝9．628，t3＝23．054，t4＝29．325，t5＝28．967，均 P ＜0．05）；与治疗前相比，观察组患者治疗后体脂百分比及 Ghrelin 与 S-TSH 的水平均较高，而 FT3、FT4水平较低，治疗前后比较差异有统计学意义（t6＝5．282，t7＝8．651，t8＝21．835，t9＝27．126，t10＝26．855，均 P ＜0．05）；经相关性分析得出：FT3及 FT4与血浆 Ghrelin 水平呈负相关（r ＝－0．44，－0．39，均 P ＜0．05）；体脂百分比及 S-TSH 与血浆Ghrelin 水平呈正相关（r ＝0．31，0．33，均 P ＜0．05）。结论甲状腺功能亢进症患者血浆 Ghrelin 水平较健康人低，且其水平高低与 FT3、FT4、体脂百分比及 S-TSH 相关，以上指标的检测均对甲状腺功能亢进症患者病情的评估具有重要价值。

Objective To study the changes of plasma growth hormone releasing peptide（Ghrelin）level and its influencing factors in patients with hyperthyroidism.Methods 55 patients with hyperthyroidism （observation group）and 55 healthy persons （control group）were selected.ELISA was used to detect plasma indicators before and after treatment.The level of body fat percentage,Ghrelin,S -TSH and FT3 ,FT4 of the two groups before and after treatment were compared,and the relationship between Ghrelin and FT3 ,FT4 ,percentage of body fat,plasma S -TSH was analyzed.Results Compared with the control group,the percentage of body fat,Ghrelin and S -TSH level in the observation group were lower,and FT3 ,FT4 levels were higher,there were significant differences between the two groups（t1 =5.021,t2 =9.628,t3 =23.054,t4 =29.325,t5 =28.967,P ＆lt;0.05）.Compared with before treatment,the body fat percentage,Ghrelin and S -TSH level of the observation group were higher after treatment,and FT3 ,FT4 levels were lower after treatment,the differences were statistically significant（t6 =5.282,t7 =8.651,t8 =21.835,t9 =27.126,t10 =26.855,P ＆lt;0.05）.The correlation analysis showed that FT3 and FT4 were negatively correlated with plasma Ghrelin level（r =-0.44,-0.39,P〈0.05）,the percentage body fat and S -TSH had positive relationship with plasma Ghrelin level （r =0.31,0.33,P〈0.05）.Conclusion The plasma Ghrelin level in the patients with hyperthyroidism is lower than healthy subjects,and its level is related with FT3 ,FT4 ,percentage of body fat and S -TSH,the detection of the above indicators has important value for the assessment of hyperthyroidism.