内源性二氧化硫在肺动脉高压中的研究进展

Research Advances of Endogenous Sulfur Dioxide on Pulmonary Hypertension

肺动脉高压是多种心、肺血管疾病发病过程中的重要病理生理环节,严重影响疾病的进展及预后,但其机制目前尚不完全清楚。因此,探索减轻肺动脉高压的方法具有重要意义。二氧化硫(SO2)是一种内源性气体小分子,具有舒张血管、降低肺动脉高压、抑制血管炎症反应、减轻血管氧化损伤、抑制血管平滑肌细胞增殖、维持细胞钙离子稳态及改善血管重构等作用。该文就SO2在肺动脉高压中的研究进展予以综述。

Pulmonary hypertension is an important pathophyslologlcal process m most ot carchopulmonary vascular diseases, seriously affecting the prognosis. However, the mechanism of pulmonary hypertension is not fully understood yet. Therefore, it is of great significance to explore methods to alleviate pulmonary hyperten- sion. In recent years, studies have shown that sulfur dioxide （ SO2 ） is an endogenous small gas molecule, which can relax vessels, alleviate pulmonary hypertension, inhibit vascular inflammation, reduce vascular oxi- dative damage, inhibit vascular smooth muscle cell proliferation, maintain intracellular calcium homeostasis, and improve vascular remodeling; Here reviews the advance in studies of SO2 on pulmonary hypertension.