摘要
作为细胞周期的关键环节,有丝分裂过程受到严格而精细的调控,随着对有丝分裂调控的探讨与拓展,也逐渐加深了人们对生命本质的理解。研究发现Polo样蛋白激酶1(PLK1)参与细胞有丝分裂调控的各环节,该文拟归纳总结Plk1在有丝分裂中诸如CDK1-Cyclin B复合物的激活、纺锤体形成、染色体分离和胞质分裂这些过程中的研究进展,并描绘PLK-1在有丝分裂调控中的作用与意义,为进一步深入探讨PLK-1与有丝分裂调控指出可能的发展方向。
As a crucial part of the cell cycle, the precise regulation of mitosis is precisely and strictly regulated, and along with the exploration in the regulation of mitosis, the understanding of life has deepene gradual!y as well. Polo-ilke kinase 1 （ PIK1 ） is involved in different processes of mitosis and here is to sumanze the functions, such as the activation of CDK1-Cychn B complex, formation of spindle, segTegatlon of chromosome and cytokinesis,and depict PLK-1 ＇s SignifiCance for mitosis and put forward the possible direc- tions of further studies.
出处
《医学综述》
2015年第20期3659-3661,共3页
Medical Recapitulate
基金
上海交通大学医学院附属第三人民医院自然科学研究基金(SYZ2013-008)
