细胞因子参与胃癌发生和发展研究进展

Progress in the Study of Cellular Factors Involved in the Occurrence and Development of Gastric Cancer

细胞因子是一类能在细胞间传递信息、发挥免疫调节的蛋白质或小分子多肽;其表达异常诱发多种疾病,包括胃癌。细胞因子参与调控细胞的癌变、侵袭与转移、血管生成,并通过调控肿瘤相关抗原的抗原递呈、淋巴细胞的活化参与胃癌的免疫逃逸,且在胃癌细胞抵抗放化疗治疗中发挥重要作用。因此,调节机体细胞因子的水平,促使机体形成对胃癌的抗肿瘤也就成为胃癌治疗的新方向。

Cytokines are a kind of protein or small molecular peptides and play a role in passing inforrna-tion between the cells or regulating immune response. The abnormal expressions ot cytokines otten cause a variety of diseases ,including stomach cancer. Cytokines are involved in the regulation of gastric cancer cellscarcinogenesis, invasion and metastasis, angiogenesis and immune escape by regulating tumor related antigen pr_e_sentation and lymphocytes activation. What＇s more, cytokines also .play an !mportan..t role in gastric cancercells resisting radiation and chemotherapy. Therefore, regulation of the body＇s cytokines levels to form the antitumor effect of gastric cancer has become a new trend for the treatment of gastric cancer.