单肺通气时降低吸入氧浓度对肺损伤的影响

Effect of Decreasing Fraction of Inspired Oxygen on Lung Injury during One Lung Ventilation

单肺通气(OLV)期间吸入纯氧能使动脉血氧分压维持在较高的水平,但也会导致吸收性肺不张和氧中毒。虽然OLV期间降低吸入氧浓度会使低氧血症的发生率增加,但在充分评估围术期患者全身情况下,适当降低吸入氧浓度(Fi O2)能够减轻肺损伤。该文主要描述OLV期间氧中毒肺损伤的机制,介绍近年来OLV期间降低Fi O2对肺损伤的研究现状。

During one lung ventilation （OLV） the inhaled 100% 02 can keep arterial oxygen partial pressure（ PaO2 ） at a high level, however it may lead to inhaled atelectasis and oxygen toxicity. Although decreasirLg FiO2 increased the incidence of hypoxemia during OLV, an intensive perioperative monitoring and appropriate low FiO2 can be helpful to reduce acute lung injury. Here is mainly to describe the mechanisms of pulmonary oxygen toxicity during OLV, and introduce the recent research status of the influence of decreasing FiO2 on lung injury during OLV.