磁共振扩散加权与灌注成像在乳腺癌肝转移早期疗效评价中的应用进展

Progress of DWI and PWI Application for Early Response Assessment of Breast Cancer Liver Metastases

乳腺癌肝转移的治疗方法主要以全身治疗为主,根据疗效选择合适的局部治疗(局部切除、经导管化疗栓塞、射频消融等),可明显提高患者的生存率。磁共振扩散加权成像(DWI)和灌注成像(PWI)是目前应用较为广泛的功能影像方法,其可区别于传统的影像学检查方法,从微观角度监测细胞密度和肿瘤微循环的改变,定量评价乳腺癌肝转移的疗效,有助于临床治疗方案的制订。

Systemic therapy is the main treatment for breast cancer with liver metastasis （BCLM）. Local therapy including metastasectomy, traseatheter hepatic arterial chemoembolization, radiofrequency ablation can increase the overall survival. Diffusion weighted imaging（DWI） and perfusion weighted imaging（PWI） are widely used imaging methods at present which can reflect the microscopic changes in tumor before mor- phologic changes, and detect the changes of cell density or tumor microcirculation to evaluate the response of BCLM, and help to establish the therapeutic regimen.