血脂水平与脑卒中患者疾病严重程度关系的研究

Study on the Relationship of Lipid Levels and Severity of Stroke

目的探讨血脂水平与不同类型脑卒中患者疾病严重程度的关系。方法选择2006年1月至2012年12月上海市静安区中心医院收治的病程<24 h的脑卒中患者260例,其中160例出血性卒中患者作为出血性卒中组,100例缺血性卒中患者作为缺血性脑卒中组,同时选择同期入院的非脑血管疾病患者100例作为对照组。将260例出血性卒中患者按照总胆固醇(TC)水平分为低TC患者组(TC<6.00 mmo L/L)组218例和高TC患者组(TC≥6.00 mmo L/L)组42例,再按三酰甘油(TG)水平分为低TG患者组(TG<2.00 mmo L/L)156例和高TG患者组(TG≥2.00 mmo L/L)104例。比较各组受试者血脂水平及疾病严重程度评分。结果出血性脑卒中组血清TC、TG和低密度脂蛋白胆固醇(LDL-C)水平显著低于缺血性脑卒中组[(4.26±0.94)mmol/L比(5.91±1.22)mmol/L,(1.67±0.66)mmol/L比(2.60±0.58)mmol/L,(2.84±1.22)mmol/L比(3.50±1.12)mmol/L],出血性脑卒中组疾病严重程度评分(SSS评分)显著低于缺血性脑卒中组[(28.7±8.8)分比(41.9±10.4)分],差异均有统计学意义(P<0.05)。低TC患者组SSS评分显著低于高TC患者组[(31±14)分比(42±13)分],差异有统计学意义(P<0.05);低TG患者组SSS评分显著低于高TG患者组[(30±12)分比(45±12)分],差异有统计学意义(P<0.05)。结论出血性脑卒中患者急性期血清TC和TG水平显著低于缺血性脑卒中患者,急性期血脂水平较低的脑卒中患者病情较严重。

Objeetive To investigate the correlation between serum lipid level and severity of different types of stroke. Methods A total of 260 stroke patients within 24 h of the onset collected in Shanghai Jing＇ an District Center Hospital from Jan. 2006 to Dee. 2012 were divided into the hemorrhagic stroke（HS） group of 160 cases and the ischemic stroke（IS） group of 100 cases. And another 100 patients with no cerebrovascu- lar diseases from the hospital during the same period were selected as the control group. The 260 cases of hemorrhagic stroke patients were divided into lower total cholesterol （ TC ） （ TC 〈 6.00 retooL/L） group of 218 cases and higher TC （ TC ≥ 6.00 mmoL/L ） group of 42 cases, and also into lower triacyglyeerol （TG） （TG 〈 2.00 mmoL/L） group of 156 cases and higher （TG ≥2.00 mmoL/L） group of 104 cases. And the relationship between the serum lipid level and severity of stroke was analyzed. Results The levels of TC ,TG and IDL-C in the hemorrhagic stroke group were significantly lower than those in the ischemic stroke group [ （4.26 ±0.94） mmol/L vs （5.91 ±1.22） mmol/L,（1.67 ±0.66） mmol/L vs （2.60 ±0.58） mmol/L, （ 2.84 ± 1.22 ） mmoL/L vs （3.50 ± 1.12） mmol/L ] （P 〈 0.05 ）. And the score of stroke severity （ SSS ） in the hemorrhagic stroke group was significantly lower than that in the ischemic stroke group [ （ 28.7 ± 8. 8 ） scores vs （41.9 ± 10. 4）scores,P 〈0.05]. SSS of patients with lower TC/TG was significantly lower than those with higher TC/TG [ （31 ± 14） scores vs （42 ± 13） scores/（30 ± 12） scores vs （45 ± 12） scores] （ P 〈 0.05 ）. Conclusion Serum rig and TG level of hemorrhagic stroke was significantly lower than ische- mic stroke, and lower lipid levels in acute stage suggest more severer stroke.