下肢动脉硬化闭塞症患者抑郁情绪发生情况及相关因素的Logistic回归分析

Logistic Regression Analysis of Depression in Arteriosclerosis Obliterans Patients and Its Risk Factors

目的探讨下肢动脉硬化闭塞（ASO）患者抑郁情绪的发生情况及其相关因素。方法采用抑郁自评量表（SDS）评估228例在北京协和医院血管外科住院治疗的成年ASO患者抑郁状态,采用单因素和多因素非条件Logistic回归方法分析ASO患者抑郁情绪的相关因素。结果 SDS评估结果显示,228例ASO患者中,有133例（58.3%）存在抑郁情绪。单因素和多因素分析结果显示,女性（OR=0.15,95%CI：0.05～0.45）,高血压（OR=4.63,95%CI：1.90～11.29）,冠心病（OR=3.62,95%CI：1.43～9.18）,Fontaine临床分期Ⅱa期（OR=20.76,95%CI：3.21～134.28）、Ⅱb期（OR=26.34,95%CI：4.20～164.97）、Ⅲ期（OR=192.28,95%CI：25.97～1423.51）、Ⅳ期（OR=291.41,95%CI：28.67～2962.21）是ASO患者发生抑郁情绪的相关因素。结论 ASO患者易出现抑郁情绪。女性、高血压、冠心病以及Fontaine临床分期Ⅱ期以上是ASO患者出现抑郁情绪的相关因素。

Objective To investigate the depression in arteriosclerosis obliterans（ ASO） patients and its risk factors. Methods The self-rating depression scale（ SDS） was applied in 228 ASO patients hospitalized in the vascular surgery department of Peking Union Medical College Hospital from March 2010 to October 2011.The risk factors of depression were analyzed by using univariate and multivariate Logistic regression analysis. Re-sults Of these 228 ASO patients,133（ 58. 3%） were found to be depressive. Univariate and multivariate analysis showed that female（ OR = 0. 15,95% CI： 0. 05-0. 45）, hypertension（ OR = 4. 63,95% CI： 1. 90-11. 29）,coronary heart disease（ OR = 3. 62,95% CI： 1. 43-9. 18）,as well as Fontaine Ⅱ a（ OR = 20. 76,95% CI： 3. 21-134. 28）,Ⅱb（ OR = 26. 34,95% CI： 4. 20-164. 97）,Ⅲ（ OR = 192. 28,95% CI： 25. 97-1423. 51）,and Ⅳ（ OR = 291. 41,95% CI： 28. 67-2962. 21） were the risk factors of depression in ASO patients. Conclusions ASO patients can easily develop depression. Female,hypertension,coronary heart disease,and FontaineⅡa,Ⅱb,Ⅲ,and Ⅳ are the risk factors of depression in ASO patients.