报告基因标记在干细胞治疗急性心肌梗死中的应用进展

Application of Reporter Gene Labeling in Stem Cell Therapy for Acute Myocardial Infarction

干细胞治疗急性心肌梗死是当下医学领域的研究热点。然而,移植后干细胞的生物学行为、治疗心肌梗死的作用机制及疗效评估等方面仍存在许多问题亟待解决。随着分子生物学的发展和进步以及分子成像技术的不断研发,移植后干细胞的示踪、转归及动态、无创、在体监测日趋成熟。本文主要讨论报告基因示踪方法在干细胞治疗急性心肌梗死中的应用,及近期相关研究成果。

Stem cell therapy for acute myocardial infarction is drawing great attention. However,the biological behavior and function mechanism of implanted stem cells remain controversial,as well as their clinical benefits. With the development of imaging probes and devices,molecular imaging enables noninvasive,dynamic tracking of stem cells in vivo. In this review,we summarize the use of various markers,especially the technique of reporter gene labeling,in the field of stem cell therapy,and highlight some recent preclinical and clinical achievements.