环状肉芽肿的研究进展

Adances in Grannuloma Annulare

环状肉芽肿是以肢端环状丘疹和结节性损害为特征的慢性炎症性皮肤病。病因不明,可能与免疫、遗传、系统性疾病、感染、药物等因素有关。无最佳治疗方法,局部外用糖皮质激素或钙调神经磷酸酶抑制剂、冷冻、PUVA、光动力疗法、富马酸酯、异维A酸、生物制剂等治疗有效。本文对环状肉芽肿的病因、临床表现和组织学特征、治疗的最新研究进展进行综述。

Grannuloma annulare is a chronic inflammatory skin disease, characterized by circular papules and nodules most commonly localized to the dorsal hands and/or feet. The etiology of GA remains unknown and several associations have been proposed including immunity, heredity, systemic diseases, infection, medicine and so on. The most efficacious and optimal treatments have not been established and topical glucocorticoid or calcineurin inhibitors, eryotherapy, PUVA, photodynamie therapy, fumaric acid esters, isotretinoin and biologic agents may be effective. This review aims to summarize the updated information of grannuloma annulare in term of etiology, clinical presentation and histologic characteristics, treatment.