巨噬细胞移动抑制因子在妇科恶性肿瘤中的研究进展

The Research Progress in Macrophage Migration Inhibitory Factor in the Development of Female Reproductive Tract Malignant Tumors

巨噬细胞移动抑制因子(MIF)是近年研究非常广泛的细胞因子之一。生理情况下,MIF可以介导炎症及免疫反应,参与胚胎期的发育、组织创伤后的修复等。MIF还被证实在妇科恶性肿瘤,如宫颈癌、卵巢癌、子宫内膜癌等的发展过程中发挥重要作用,并与肿瘤的恶性程度密切相关。MIF可以激活多种信号通路,如c-Jun氨基末端激酶(JNK/cJun)、磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)等,通过促进细胞增殖、黏附、转移、血管新生、上皮间质转化和增强免疫抑制等方式加速肿瘤的发展。此外,许多研究都显示,抑制MIF的分泌及生物学活性可以有效减慢,甚至逆转肿瘤的发展,有效的MIF抑制剂有望成为治疗癌症的新希望。

Macrophage migration inhibitory factor（MIF） is one of the most widely researched cytokines in recent years.Under physiological conditions, MIF mediates inflammation and immune response in embryonic development, tissues repair after trauma. Recently, MIF has also been proved to play a pivotal role during the development of gynecologic malignant tumors, such as cervical cancer, ovarian cancer, endometrial cancer and so on, and it also has a close relationship with the malignant degree of tumors. MIF can activate a variety of signaling pathways, such as JNK/c-Jun and PI3K/Akt. MIF can accelerate the progression of malignant tumors through promoting cells proliferation, adhesion, metastasis, angiogenesis, immune suppression and so on.Studies have shown that inhibition of secretion and biological activity of MIF can effectively slow down or even reverse tumor development. MIF antagonist may be a new therapeutic target for tumors.