蓝连儿童清热巴布贴基质处方的优化研究

Study on the Optimization of Matrix Formula of Lanlian Ertong Qingre Cataplasm

目的:优选蓝连儿童清热巴布贴的基质处方。方法:以黏着力、剥离强度以及感官描述评价为指标,采用正交试验方法优选巴布贴的基质骨架材料(聚丙烯酸钠-甘羟铝-酒石酸-甘油)配比;单因素试验筛选黏合剂和填充剂种类;以连翘苷体外透皮量为指标筛选促渗剂氮酮的加入量。结果:基质骨架材料的最优配比为聚丙烯酸钠-甘羟铝-酒石酸-甘油(4.0∶0.8∶0.4∶15),黏合剂为聚乙烯吡咯烷酮K90,填充剂为高岭土,氮酮加入量为2.0%;验证试验显示,所制巴布贴外观质量佳,可黏住5号或6号钢球,剥离强度值为7.5 N,各指标评分的RSD均小于4%(n=3)。结论:优选出的蓝连儿童清热巴布贴基质配方简单、稳定、成型性好。

OBJECTIVE：To optimize the matrix formula of Lanlian ertong qingre cataplasm. METHODS：Taking adhesion force,peel strength and sensory description as index,the ratio of matrix framework material（sodium polyacrylate-gan hydroxyl aluminum-tartaric acid-glycerin）was optimized with orthogonal test. The single factor test was adopted to select adhesive and filler;the amount of penetrating agent azone was screened using the in vitro penetration amount of phillyrin. RESULTS：The best matrix ratio of Lanlian ertong qingre cataplasm was sodium polyacrylate-gan hydroxyl aluminum-tartaric acid-glycerin（4.0 ∶ 0.8 ∶ 0.4 ∶ 15）;PVP K-90 was used as adhesive,and bolus alba as filler;penetration enhancers azone accounted for 2.0%. Validation test showed,prepared cataplasm had good appearance,could stick on the 5th or the 6th ball;it＇s peel strength was 7.5 N;all RSDs of score were lower than 4%（n=3）. CONCLUSIONS：The optimized matrix formula of Lanlian ertong qingre cataplasm is simple,stable and good in molding.