5-氯-6-甲基吡嗪-2-羧酸甲酯的合成

Synthesis of Methyl 5-Choloro-6-methyl-2-pyrazinecarboxylic Acid

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摘要以二氨基马来腈和丙酮酸为起始原料,经过环合、酸水解、酯化和氯化反应,以54.9%的总收率得到5-氯-6-甲基吡嗪-2-羧酸甲酯,路线原料易得,操作简单,并通过优化减少了三废的排放。 Methyl 5-choloro-6-methyl-2-pyrazinecarboxylic acid is prepared from diaminomaleonitrile and pyruvic acid by cyclization, hydrolysis, esterification and chlorination reaction in total yield of 54.9%.

作者张世界张玲玲程杰兵陈海南王晓钟

机构地区浙江新三和医药化工股份有限公司浙江大学化学工程与生物工程学院

出处《浙江化工》 CAS 2015年第10期24-27,共4页 Zhejiang Chemical Industry

关键词二氨基马来腈丙酮酸 5-氯-6-甲基吡嗪-2-羧酸甲酯 diaminomaleonitrile pyruvic acid methyl 5-choloro-6-methyl-2-pyrazinecarboxylic acid

分类号 TQ25 [化学工程—有机化工]

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5-氯-6-甲基吡嗪-2-羧酸甲酯的合成

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