针灸治疗阿尔茨海默病机制研究进展（英文）

Review of mechanisms of acupuncture in treatment of Alzheimer's disease

阿尔茨海默病是一种以记忆障碍为主的神经退行性疾病。针灸作为中国传统医学的重要组成部分在临床上早已经应用于阿尔茨海默病的治疗,但其机制并不明确。过去的几十年来,世界上若干国家的科学家致力于其治疗有效性及机制的研究。实验室研究表明,针灸可以抑制对神经系统有害的因素产生,促进具有保护作用的因素,从而发挥其对阿尔茨海默病的治疗效应。另一方面,随着功能磁共振的发展,研究人员发现针灸可以引发不同脑区的激活或者去激活以及调节脑区之间功能连接,而这种脑效应可能是针灸治疗阿尔茨海默病的重要机制之一。

Alzheimer＇s disease（ AD） is a progressive neurodegenerative disorder characterized by cognitive impairment. Acupuncture,an important component of Traditional Chinese Medicine,has been used in treatment of dementia for many years,but the mechanism is still unclear. In the past few decades,researchers in manyparts of the world have devoted to studying the essence of acupuncture treatment on AD. Conclusion drawn from experiments included that acupuncture plays a protective role through inhibiting harmful factors and promoting the beneficial ones. On the other side,using f MRI,researchers concluded that acupuncture could evoke activation or deactivation and modulate the functional connectivity between distinct brain regions,these effect of acupuncture on brain would be another important mechanism.