独活寄生汤加减对类风湿性关节炎临床疗效及实验室指标的影响

Influence of Duhuo Jisheng Decoction on Rheumatoid Arthritis Patients and Its Effect on Laboratory Indicators

目的:探讨独活寄生汤加减联合西药对类风湿性关节炎临床疗效分析及患者实验室指标的影响。方法:类风湿性关节炎患者76例根据随机分组法分为治疗组和对照组各38例。治疗组采用独活寄生汤加减联合西药治疗,对照组仅采用西药治疗。两组疗程均为3个月。对比分析两组治疗前后实验室指标水平变化、治疗后临床疗效及治疗期间不良反应发生情况。结果:治疗组治疗后RF、ESR及CRP水平变化显著低于对照组(P<0.05);两组治疗后TNF-α、IL-6水平变化较治疗前显著减少(P<0.05);治疗组治疗后TNF-α、IL-6水平变化显著低于对照组(P<0.05);治疗组总有效率(95.74%)显著高于对照组(71.05%)(P<0.05);治疗期间均未见明显不良反应。结论:独活寄生汤加减联合西药对类风湿性关节炎临床疗效明显,可明显改善患者实验室指标,从而改善患者症状、体征。

Objective： To investigate the influence of Duhuo Jisheng Decoction combined with western medicine for rheumatoid arthritis patients and its effect on laboratory parameters. Methods： 76 patients with rheumatoid arthritis were randomly divided into treatment group（ n = 38） and control group（ n = 38）. The treatment group received Duhuo Jisheng Decoction combined with western medicine and western medicine treatment in control group. The treatment lasted three months. Comparative analysis on laboratory parameters changes,the therapeutic efficacy and adverse reactions during clinical treatment was carried out. Results： After treatment,RF,ESR and CRP levels were significantly lower than the control group＇s（ P〈 0. 05）. Two groups＇ TNF- α and IL- 6 levels after treatment were significantly reduced（ P 〈0. 05）.The treatment group＇s TNF- α and IL- 6 levels after treatment were significantly lower than the control group＇s（ P〈 0. 05）. The treatment group＇s total effective rate（ 95. 74%） was significantly higher than that of the control group（ 71. 05%）（ P 〈0. 05）. There was no adverse reaction during the treatment period. Conclusion： Duhuo Jisheng Decoction combined with Western medicine has clinically significant effect on rheumatoid arthritis and can significantly improve patients＇ laboratory tests to improve patient symptoms and signs.