摘要
视网膜新生血管性疾病是致盲的主要原因。趋化因子受体7(C-C chemokine receptor type 7,CCR7)可通过细胞外信号调节激酶(extracellular signal regulate kinase,ERK)通路促进血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达,导致血管渗漏、血管内皮细胞增生以及新生血管形成等改变。趋化因子受体7的检测可指导视网膜新生血管性疾病的诊治。
Retinal neovascularization diseases are the major causes of blindness. C-C chemokine receptor type 7 （CCR7） can promote the expression of vascular endothelial growth factor （VEGF） through the extracellular signal regulated kinase （ERK） pathway, leading to vascular leakage, proliferation of vascular endothelial cell, neovascularization and etc. The detection of CCR7 can guide the diagnosis and treatments of retinal neovascularization diseases.
出处
《国际眼科杂志》
CAS
2015年第11期1905-1908,共4页
International Eye Science
基金
辽宁省科技计划项目基金资助(No.2010225034)
辽宁省自然科学基金资助(No.20102281)~~
关键词
趋化因子受体7
胞外信号调节激酶
血管内皮生长因子
视网膜新生血管
C - C chemokine receptor type 7
extracellular signal regulate kinase
vascular endothelial growth factor
retinal neovascularization
