应用3D OCT测量中老年人正常眼视网膜神经纤维层厚度

Retinal nerve fiber layer thickness of middle aged or elderly people measured by 3D optical coherence tomography

目的：建立我国40~69岁中老年人正常眼视网膜神经纤维层（retinal nerve fiber layer,RNFL）厚度的参考值范围,为青光眼的早期诊断提供参考依据。方法：用Topcon 3D OCT-2000（Ver 8.0）对40~69岁中老年人90例180眼以视乳头为中心、直径为3.4mm的环形线的RNFL厚度进行测量,并记录各个钟点位、各象限、平均RNFL厚度。对数据进行统计学分析,分析正常眼RNFL厚度与年龄、性别、眼别的关系,得出中老年人正常眼RNFL厚度特点及参考值。结果：40~69岁中老年人正常眼RNFL厚度曲线分布呈双峰型,下方〉上方〉鼻侧〉颞侧;10∶00位、5∶00位、6∶00位、上方RNFL厚度随年龄增长而变薄,10∶00位差异有统计学意义（P〈0.05）,其余均无统计学差异（P〉0.05）;除11∶00位外,其余RNFL厚度与性别无关;11∶00位、12∶00位、1∶00位、4∶00位、上方及鼻侧RNFL厚度与眼别有关,差异有统计学意义（P〈0.05）。结论：Topcon 3D OCT-2000可以有效测量40~69岁中老年人RNFL厚度,为青光眼的早期诊断提供依据。

AIM：To build the reference values of normal eye retinal nerve fiber layer（RNFL） thickness on middle aged people between 40 ~69 years old,and infer the baseline data for early diagnosis of glaucoma.M ETHODS：A total of 180 eyes from 90 healthy subjects（age ranged from 40 ~69 years old） were recruited for this study.Topcon 3D optical coherence tomography（OCT）-2000（Ver 8.0） was used to measure RNFL thickness.Each subject was performed circular scans around the optic nerve with a circle size of 3.4mm.Clock-hour,quadrant and total average RNFL thicknesses were recorded.The data was analyzed with SPSS statistical.The relationship between age,gender and laterally was analyzed,and the reference value for normal eye RNFL thickness parameters was obtained,RESULTS：Normal RNFL thickness distribution was bimodal curve type in 40 ~69 year-old middle aged or elderly people.RNFL thickness was decreased for temporal quadrant,followed by nasal,superior,inferior.RNFL thickness at 10 o＇clock,5 o＇clock,6 o＇clock,superior got thinner with age prolong.Except 10 o＇clock（P〈0.05）,there were no significant differences in age（P〉0.05）.The RNFL thickness at 11 o＇clock was associated with different gender,the RNFL thickness at 11 o＇clock,12 o＇clock,1o＇clock,4 o＇clock,superior,nasal was associated with different eyes,the differences was statistically significant between different eyes（P〈0.05）.CONCLUSION：Topcon 3D OCT-2000 is effectively used to measure the RNFL thickness of 40 ~69 years people and provide diagnostic basis for early diagnosis of glaucoma.