抗菌药物服用时间对预防结直肠癌手术切口感染效果的影响

The impact of antibiotics taking time in preventing colorectal cancer surgery incision infection effects

目的：探讨抗菌药物服用时间对预防结直肠癌手术切口感染效果的影响。方法选取2010年9月—2015年3月在达县中医院就诊的141例行结直肠癌手术的患者，随机分为 A 组、B 组、C 组，各47例。3组患者均给予新霉素，A 组在术前0.5~1.0h（即麻醉诱导期）服用新霉素，B 组在术前1~2d 服用新霉素，C 组在术后0.5~1.0h 服用新霉素，比较3组患者的手术切口感染率。结果 A 组手术切口感染率为2.13％，B 组手术切口感染率为6.38％，C 组手术切口感染率为6.38％，B 组与 C 组手术切口感染率比较，差异无统计学意义（P ﹥0.05），B 组与 C组手术切口感染率均高于 A 组，差异有统计学意义（P ﹤0.05）。结论结直肠癌手术中为防止术后切口感染服用抗菌药物的最佳时间是术前0.5~1.0h，医生应准确把控给予抗菌药物的时间，预防手术切口感染。

Objective To study the impact of antibiotics taking time in preventing colorectal cancer surgery incision infection effects. Methods From March 2013 to March 2015 in Hospital of Traditional Chinese Medicine of Da County,a total of 141 patients with colorectal cancer surgery were chosen and randomly divided into group A,group B,group C,47 cases in each group. Three groups were all treated with neomycin,group A was treated with neomycin at 0. 5 ~ 1h before surgery（induc-tion of anesthesia）,group B was treated with neomycin at 1 ~ 2d before surgery,group C was treated with neomycin at 0. 5 ~ 1h after surgery,the incision infection rate of the three groups were compared. Results The incision infection rate of group A was 2. 13% ,the incision infection rate of group B and group C were both 6. 38% ,the incision infection rate between group B and group C showed no significant differences（P ﹥ 0. 05）,and they were higher than group A,the differences were statistically sig-nificant（P ﹤ 0. 05）. Conclusion The best antibiotics taking time in preventing colorectal cancer surgery incision infection is 0. 5 ~ 1h before surgery,the doctor should be accurate about the taking time to prevent incision infection.