小鼠对鼠伤寒沙门氏菌感染免疫应答的研究进展

Research Progresses on Immunity Response of Mice to Salmonella Typhimurium Infection

小鼠鼠伤寒沙门氏菌感染后,会引发一系列的肠道和全身性的疾病,这是一种类似于人感染伤寒沙门氏菌的疾病。在感染的早期,天然免疫系统能迅速对入侵的细菌做出反应,吞噬细胞的活化以及炎症因子的产生能在一定程度上抑制鼠伤寒沙门氏菌的增殖,而在感染的后期,对于有效地控制和消灭细菌,获得性免疫是必要的。鼠伤寒沙门氏菌的感染能诱导特异性CD4+和CD8+T细胞的增殖,从而引发强烈的免疫应答,在此过程中也会产生大量的B细胞。特异性T细胞以及B细胞介导的免疫反应能有效地抵御细菌的侵染。总而言之在天然免疫系统和获得性免疫系统协调作用下,实现了对宿主的免疫保护。

Salmonella typhimurium（S. typhimurium） infection can cause a range of intestinal and systemic diseases on mice with the same symptoms as human after infection with Salmonella typhi. In the early stage of infection, innate immunity is rapidly initiated after oral infection. The activation of phagocytes and the production of inflammatory cytokines can inhibit the proliferation of S. typhimurium, but for an effective control and eradication of bacteria, acquired immunity is essential. S. typhimurium infection can induce the proliferation of specific CD4^＋and CD8^＋T cells and results in immune response to the infection. In the process, a large number of B cells were generated. The coordination of specific T cells and B cells can resist to Salmonella infection. Overall, innate immunity combined with acquired immunity could control S. Typhimurium infection and protect host against infection.