肠内营养、肠外营养对改善高血压脑出血患者免疫功能的比较研究

Comparison between EN and TPN on Immune Function of Hypertensive Intracerebral Hemorrhage

目的:探讨不同营养方式对高血压脑出血患者免疫功能的影响。方法:将120例高血压脑出血患者随机分成3组,A组为肠内营养EN组(42例)、B组为胃肠外营养TPN组(45例)、C组为传统鼻饲对照组(33例),比较3种营养方式对免疫功能的影响以及营养指标变化。结果:入组前3组研究对象的T淋巴细胞亚群(CD4+、CD8+、CD4+/CD8+),免疫球蛋白IgA、IgM、IgG,以及血常规总淋巴细胞计数(Lym)、红细胞计数(RBC)、血清白蛋白(ALB)、血糖和甘油三酯,组间比较差异无统计学意义(P>0.05)。治疗后3组间CD4+/CD8+、免疫球蛋白IgA、IgG,血清白蛋白(ALB)、血糖比较差异有统计学意义(P<0.05或P<0.01)。结论:肠内营养能更好促进高血压脑出血患者细胞免疫功能的恢复,增强患者抗感染能力并改善营养状态。

Objective:To explore the effects of EN and TPN on hypertensive intra-cerebral hemorrhage (HICH).Methods:120 patients with hypertensive intra cerebral hemorrhage were randomized into three groups,the group A is enteral nutrition,EN(42 cases),the group B is Parenteral nutrition,TPN(45 cases), The group C is Traditional nasogastric group (33 cases),Compare affects of three nutrition methods on im-mune function and the change of nutritional indicators.Results:There was no significant difference among three groups on T lymphocyte subsets (CD4+,CD8+,CD4+/CD8+),immunoglobulin IgA,IgM,IgG, and total blood lymphocyte count (Lym),red blood cell count (RBC),serum albumin (ALB),blood glucose and triglycerides (P>0.05).After treatment,There exists significant difference among groups on CD4+/CD8+,immunoglobulin IgA,IgG,serum albumin (ALB),blood glucose(P<0.05 or P<0.01).Conlusion:Enteral nutrition can better improve immune function ,resistance to infection and nutritional status in pa-tients with hypertensive cerebral hemorrhage .