DWI在肝硬化后肾功能损害应用价值的初步研究

A Preliminary Study on the Value of DWI in Treating Impaired Renal Function after Cirrhosis

目的:通过测量肝硬化后肾脏MR扩散加权成像(DWI)中的表观系数(ADC)值,评价DWI在肝硬化后早期肾功能损害的价值。方法:随机收集住院肝硬化患者行常规MR检查及DWI成像,DWI成像时b值分别采用500s/mm2、800s/mm2,按以血清胱抑素C(Cys C)>1.03mg/L为肾功能损害标准分组,(Cys C)>1.03mg/L为阳性组,(Cys C)<1.03mg/L为阴性组。扫描结束后获得弥散加权图像,利用MR主机内带软件重建ADC图,随后在得到的ADC图中勾画出感兴趣区测量ADC值。对所得数据进行统计分析,根据研究目的和资料的性质选用相关分析及方差分析进行假设检验。结果:所有正常者和研究病例在不同b值下的正常组、阴性组、阳性组ADC值,ADC500值分别(3.16.±0.010)mm2/s、(2.81±0.052)mm2/s、(2.52±0.083)mm2/s,阳性组与正常组、阴性组比较有明显差异(P<0.01)。ADC800值分别(2.75.±0.049)mm2/s、(2.72±0.012)mm2/s、(2.17±0.023)mm2/s,阳性组与正常组、阴性组比较有明显差异(P<0.01)。结论:DWI在肝硬化后早期肾功能变化评估中具有一定的应用价值。

Objective:To measure the value of apparent diffusion coefficient(ADC)according to renal MR and diffusion weighted imaging (DWI)after cirrhosis and to evaluate the value of DWI to impaired renal function in the early stage.Methods:Randomly collect hospitalized patients with cirrhosis and carry out rou-tine MR examination and DWI,when operating DWI,the value of b were defined to 500s/mm2 ,800s/mm2 , group them based on the standard that renal function was believed to be impaired if Cystatin C (Cys C)>1.03mg/L ,in positive group,Cys C>1.03 mg/L,in negative groupCys C)<1.03mg/L.DWI were acquired after scanning,reconstruct ADC map with the software within the host of MR,then outline the areas expec-ted in the figure of ADC and measure the value of ADC ,make statistical analysis on the data obtained ,se-lect correlation analysis and variance analysis to carry out hypothesis testing according to the the research purpose and the property of the data.Results:The ADC500 value of normal group ,negative group and posi-tive group in the context of different of different b values was (3.16.±0.010)mm2/s,(2.81±0.052)mm2/s, (2.52±0.083)mm2/s respectively,to compare positive group with normal group and negative group,the differences were obvious (P<0.01).The value of ADC800 was (2.75.±0.049)mm2/s,(2.72±0.012)mm2/s,(2.17±0.023)mm2/s respectively,to compare positive group with normal group and negative,the differ-ences were obvious(P<0.01).Conclusion:DWI is of some value in the evaluation on the changes of renal function in the early stage after cirrhosis .