乙型肝炎患者两种常见模式HBV-DNA与肝功能检测结果的分析

Analysis on detection results of HBV-DNA and liver function in hepatitis B patients of two common modes

目的了解"大三阳"与"小三阳"患者血清中HBV-DNA定量、肝功能指标的相互关系及意义。方法选择2014年1-6月到武汉大学人民医院感染科就诊的651例乙型肝炎(乙肝)患者,检测其血清学指标"两对半"和生化指标8项。按血清学结果分为A("小三阳"组)、B("大三阳"组)、C(健康对照组)3组,对其检测结果进行分析。结果 A与B组患者的年龄、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)活力的差异有统计学意义(P<0.01)。随着HBV-DNA载量的增加,A和B组的ALT和AST水平相应升高。结论 "大三阳"患者肝功能损伤程度及HBV-DNA含量高于"小三阳"患者,但肝功能与乙肝感染病程不呈平行关系。

[Objective]To study the relationship of serum HBV-DNA quantitative level and liver function indexes in hepatitis B patients of two common modes,and analyze its clinical significance. [Methods]651 hepatitis B patients who were treated in the Infection Department of Renmin Hospital of Wuhan University from January to June 2014 were enrolled in this study,and the serum indexes（HBsAg,HBsAb,HBeAg,HBeAb and HBcAb） and 8 biochemical indexes were detected. According to the results,the patients were divided into 3 groups：group A[HBsAg（＋）,HBeAb（＋）,HBcAb（＋）],group B[HBsAg（＋）,HBeAg（＋）,HBcAb（＋）]and group C（Healthy controls）,and the results were analyzed.[Results]The differences in age,ALT activity and AST activity were statistically significant between group A and group B（P〈0.01）.With increasing of HBV-DNA load,the ALT and AST levels in group A and group B increased. [Conclusion]The liver function damage degree and HBV-DNA level in group A[HBsAg（＋）,HBeAb（＋）,HBcAb（＋）]are higher than those in group B [HBsAg（＋）,HBeAg（＋）,HBcAb（＋）].However,there is no a parallel relationship between liver function and infection stage of hepatitis B.