呼吸道合胞病毒肺炎患儿中医辨证分型与实验室指标的相关性

Relationship between TCM syndrome differentiation and laboratory examination of children with respiratory syncytial virus pneumonia

目的研究小儿呼吸道合胞病毒(RSV)肺炎的中医辨证分型规律、证候出现频数及不同中医证型与C反应蛋白、肌酸激酶同工酶等指标的关系。方法通过对146例RSV肺炎患儿的病例四诊资料的回顾性分析,建立中医证候信息数据库,检测相关指标,探讨其与中医证型分布规律的相关性。结果 146例RSV肺炎以风热闭肺、毒热闭肺、痰热闭肺居多,占90.42%;证候出现概率以咳嗽、气促、气喘、痰鸣最高,频率达80.14%;风热闭肺型病程天数明显短于痰热闭肺型和毒热闭肺型(P<0.01);毒热闭肺型患儿年龄明显小于其他证型患儿年龄(P<0.01);C反应蛋白数值,痰热闭肺型高于风热闭肺型(P<0.05),毒热闭肺型与风热闭肺型比较,P<0.01;肌酸激酶同工酶数值,毒热闭肺型高于风热闭肺型(P<0.01)。结论 146例合胞病毒肺炎主要以风热闭肺、毒热闭肺、痰热闭肺型最为常见,微观实验室检查与中医证候存在关联。

Objective To study the syndromes distribution regularity of children with RSV Pneumonia, symptoms appear frequency and the correlation between TCM syndrome types of RSV pneumonia and C-reactive protein level ,creatine ki- nase isoenzyme MB. Methods Retrospective analysis of 146 cases of children with RSV pneumonia with four TCM diag- nostics data was carried out to establish an information databases of syndromes, to detect Relevant indicators, searching for the relationship among indicators and syndrome. Results The 146 cases of RSV pneumonia was mostly in phlegm- heat blocking the lung syndrome ,wind-heat blocking the lung syndrome and toxic-heat blocking the lung syndrome ,ac- counting for 90.42% ;Cough, shortness of breath is higher in symptoms appear frequency,to 80.14% ;The average dura- tion of wind-heat blocking the lung syndrome was shorter than those phlegm-heat blocking the lung syndrome （P 〈 0.01 ） ;an average age of toxic-heat blocking the lung syndrome was less than those syndrome （P 〈 0.01 ） ;C-reac- tive protein values ,phlegm heat type lung numerical closed on the high side ,compared with wind-heat closed type lung syndrome （P 〈 0.05 ）, toxic-heat closed type lung syndrome compared with wind-heat closed type lung syndrome （ P 〈 0.01 ） ;CK-MB lever was higher in toxic-heat blocking the lung syndrome than wind-heat blocking the lung syndrome （P 〈 0.01 ）. Conclusion The 146 cases of children with RSV pneumonia were mainly focused on wind-heat blocking the lung syndrome, toxic-heat blocking the lung syndrome and phlegm-heat blocking the lung syndrome ,there were associa- tion between the micro laboratory examination and TCM syndrome.