系统性红斑狼疮病人血清BAFF及IL-17水平及意义

SERUM LEVELS OF BAFF AND INTERLEUKIN 17IN SYSTEMIC LUPUS ERYTHEMATOSUS

目的探讨B细胞活化因子(BAFF)及白细胞介素17(IL-17)在系统性红斑狼疮(SLE)病人血清中的表达水平及其意义。方法选取我院风湿免疫科住院SLE病人48例,体检中心同期健康体检者20例作为对照。采用ELISA方法检测研究对象血清中BAFF和IL-17的水平。结果 SLE组血清BAFF水平较对照组明显升高(t=3.256,P<0.05)。SLE组血清IL-17水平较对照组明显升高(t=4.004,P<0.05);且SLE初治组IL-17水平高于经治组(t=3.625,P<0.05);有狼疮性肾炎组IL-17水平高于无狼疮性肾炎组(t=3.357,P<0.05)。SLE组血清BAFF与IL-17水平呈正相关(r=0.478,P<0.05)。结论 BAFF及IL-17可能参与了SLE的发病,且二者存在一定的关联;SLE病人血清BAFF水平可以作为观察疾病活动的指标;血清IL-17水平可以作为预测狼疮肾炎的指标,并有望成为狼疮肾炎新的治疗靶点。

Objective To investigate the expressions and significance of B-cell activating factor（BCAF）and interleukin17（IL-17）in systemic lupus erythematosus（SLE）. Methods Forty-eight SLE patients who hospitalized in our department were selected for the present study,and 20 healthy individuals form Medical Examination Centre served as controls.Employing ELISA assay,serum BCAF and IL-17 were measured. Results Compared with the control group,the serum levels of BCAF（t=3.256,P〈0.05）and IL-17（t=4.004,P〈0.05）in SLE group were higher.IL-17 level in the initial-treatment group was higher than that in after-treatment group（t=3.625,P〈0.05）,and that in lupus nephritis was higher than that in non-lupus nephritiss（t=3.357,P〈0.05）.In SLE,BCAF was positively correlated with IL-17（r=0.478,P〈0.05）. Conclusion B-cell activating factor and Interleukin 17 are probably involved in the development of systemic lupus erythematosus,and there is a certain correlation between the two markers.Serum level of B-cell activating factor may be used as a marker to observe the action of the disease,and serum Interleukin 17 to predict lupus nephritis and is expected to become a new target point for treatment of this type of nephritis.