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Notch信号通路调控OPG/RANKL/RANK系统对骨质疏松椎体骨折影响的研究进展 被引量：5

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摘要 骨质疏松症（Osteoporosis，OP）是一种比较常见的全身性骨骼系统疾病，患有此病者的骨量减少，骨组织微观结构出现退化，进而导致骨头脆化，容易出现骨折现象。骨质疏松症影响全世界2亿女性人口，是全球亟待探索和解决的老年慢性疾病之一，严重威胁着老年人的健康，已被WHO列为十大最严重疾病之一.
作者 李永贤 张顺聪 郭丹青
机构地区 广州中医药大学 广州中医药大学第一附属医院
出处 《中国中医骨伤科杂志》 CAS 2015年第11期73-77,共5页 Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金 广东省科技厅社会发展项目(2012B031800208) 广东省自然基金项目(S2013010015870)
关键词 NOTCH信号通路 OPG/RANKL/RANK系统 骨质疏松椎体骨折
分类号 R68 [医药卫生—骨科学]
  • 相关文献

参考文献38

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二级参考文献138

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共引文献126

同被引文献70

  • 1王剑,李屹,王实,刘剑辉,刘文艳,宋光熠,郑洪新.基于骨组织Runx2、Osterix启动子甲基化探究鹿茸中药复方对去卵巢骨质疏松症大鼠的疗效机制[J].世界科学技术-中医药现代化,2020,22(5):1744-1749. 被引量：15
  • 2李倩楠,陈大琴,吕春明,何翔,贺旭峰,杨莉莉,陈文君,丁佩军,张慧敏.淫羊藿苷通过Nrf2/HO-1/GPX4信号通路调节破骨细胞铁代谢的机制研究[J].上海中医药大学学报,2022,36(S01):232-239. 被引量：10
  • 3张丽君,王艺璇,胡泽兵,王可,李高志,石菲,曹新生,张舒.表观遗传学调控骨骼细胞功能的研究进展[J].解放军医学院学报,2019,40(12):1199-1202. 被引量：5
  • 4王志文,张爱国,袁强,赵文毅,孙丽丽,贾秀荣,程爱国.麝香乌龙丸抗炎及镇痛药理研究[J].时珍国医国药,2007,18(3):584-586. 被引量：30
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  • 10Narducci P, Bareqqi R, Nicolin V. Receptor activator for nuclear factor kappa B ligand ( RANKL ) as an osteoim-mune key regula-tor in hone physiology and pathology[J].Acta Histochem,2009,10: 1016-1025.

引证文献5

二级引证文献49

中国中医骨伤科杂志
2015年 第11期

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