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抗癌抗生素格尔德霉素衍生物17AAG的研究进展 被引量：1

Advances on Anticancer Antibiotic Geldanamycin Derivative 17AAG
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摘要 格尔德霉素是一种苯醌安莎霉素类抗生素,有极强的抗肿瘤活性,其衍生物17AAG(17-丙烯胺-17-去甲氧基格尔德霉素)是格尔德霉素的17位甲氧基被烯丙胺基取代所得,与格尔德霉素相比,其毒性更低,抗癌活性更高。综述17AAG的作用机制、治疗应用、药代动力学、毒性等研究进展。 Geldanamycin is a benzoquinone ansamycin antibiotic with strong anti-tumor activity. Its derivative 17AAG（17-allylamino-17-demethoxy-geldanamycin） is obtained by substituting allylamine for geldanamycin＇s 17-methoxy, which has shown lower toxicity and higher antitumor activity, compared with geldanamycin.The advances on the mechanism of action, therapeutic use, pharmacokinetics and toxicity of 17 AAG were reviewed.
作者 易凤炎 周长林 顾觉奋
机构地区 中国药科大学生命科学与技术学院 南通秋之友生物科技有限公司
出处 《药学进展》 CAS 2015年第8期598-602,共5页 Progress in Pharmaceutical Sciences
关键词 17AAG 抗癌抗生素 作用机制 治疗应用 药代动力学 毒性 17-AAG anticancer antibiotic mechanism of action therapeutic use pharmacokinetics toxicity
分类号 R96 [医药卫生—药理学]
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药学进展
2015年 第8期

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