瘦素信号与瘦素抵抗机制研究进展

Leptin Signalings and Leptin Resistance

瘦素(leptin)调控机体能量平衡(energy balance)和代谢稳态(metabolic homeostasis)。瘦素功能异常与肥胖和糖尿病等代谢性疾病密切相关。瘦素激活中枢代谢调控神经元,启动瘦素信号转导(leptin signalings),以发挥生理功能。瘦素抵抗(leptin resistance),表现为血浆瘦素水平升高,但作用减弱或消失。目前认为,下丘脑代谢调控神经元的瘦素信号转导异常是瘦素抵抗的主要机制之一。本文综述近五年来瘦素信号转导与瘦素抵抗机制研究进展。

Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis.Im-pairment of leptin function is closely involved in the pathogenesis of obesity,diabetes mellitus and some other metabolic diseases.Leptin initiates intracellular signal transductions in the leptin-receptor-express-ing neurons in the central nervous system to exert its physiological functions.The fact that high circulat-ing levels of leptin partially or completely fail to promote weight loss in obesity has given rise to the notion of ＆quot;leptin resistance＆quot;.Recently,the impairment of leptin signalings in the hypothalamus has been regar-ded as a critical contributor to leptin resistance.In this review,the studies on leptin signaling and leptin resistance are summarized with an emphasis on the progress made during the last five years.