补气通滞汤联合温胆汤加减对急性脑梗死患者炎性因子水平的影响

The Influence of Decoction for Nourishing Qi and Dredging Obstruction in Combination with Gallbladder-Warming Variant Decoction on Inflammatory Factors of Patients with Acute Cerebral Infarction

目的:观察补气通滞汤联合温胆汤加减对急性脑梗死患者炎性因子水平的影响。方法:将134例急性脑梗死患者,随机分为对照组和治疗组,每组各67例。对照组采用常规治疗方案,治疗组在对照组的基础上予以补气通滞汤联合温胆汤加减。比较两组治疗前后中医证候积分、神经功能缺损评分(NIHSS)及Barthel自理能力指数(BI)变化差异,记录其格拉斯哥预后(GOS)分级情况,分析治疗前后血清C反应蛋白(CRP)、白介素-1β(1L-1β)、肿瘤坏死因子-α(TNF-α)、血浆同型半胱氨酸(Hcy)等炎性因子水平变化情况。结果:治疗后,两组患者中医证候评分及NIHSS评分均较治疗前显著降低,BI则显著提升,且治疗组各指标变化幅度均大于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者CRP、1L-1β、TNF-α及Hcy等炎性因子均较治疗前显著降低,且治疗组与对照组比较,差异具有统计学意义(P<0.05);治疗组GOS分级优良率为79.1%,显著高于对照组的52.2%,两组比较,差异具有统计学意义(P<0.05)。结论:补气通滞汤联合温胆汤可显著降低急性脑梗死患者的炎性因子水平。

Objective： To observe the influence of Decoction for Nourishing Qi and Dredging Obstruction（ DNQDO） in combination with Gallbladder-Warming Variant Decoction on inflammatory factors of patients with acute cerebral infarction. Methods： One hundred and thirty- four patients with acute cerebral infarction were chosen as the research objects and randomly divided into the control group and the treatment group,with 67 cases in each group. The ones in the control group were given routine treatment,while the ones in the treatment group were added DNQDO in combination with Gallbladder-Warming Variant Decoction based on the treatment of the control group. Then TCM syndrome score,NIHSS,Barthel BI changes before and after the treatment of the two groups were compared; GOS grading was recorded; The changes of inflammatory factors including CRP,1L-1β,TNF-αand Hcy before and after the treatment of the two groups were analyzed. Results： After the treatment,TCM syndrome score and NIHSS score of the two groups were significantly reduced compared with before the treatment,while their BI were significantly improved; The change range of each indicator in the treatment group was larger than that of each in the control group; And the differences between them had statistical significance（ P〈0. 05）. After the treatment,inflammatory factors including CRP,1L-1β,TNF-αand Hcy of the two groups were significantly reduced compared with before the treatment; And the differences between the two groups had statistical significance（ P〈0. 05）. After the treatment,GOS grading excellent rate of the treatment group was 79. 1%,which was significantly higher than that（ 52. 2%） of the control group; And the difference between the two groups had statistical significance（ P〈0. 05）. Conclusion： DNQDO in combination with Gallbladder-Warming Variant Decoction can significantly reduce inflammatory factors of patients with acute cerebral infarction.