苦参素联合复方丹参注射液治疗慢性乙型肝炎合并肝纤维化54例

Fifty-Four Cases of Chronic Hepatitis B Merged with Liver Fibrosis Treated with Kushenin in Combination with Compound Radix Salviae Miltiorrhizae Injection

目的:观察苦参素联合复方丹参注射液治疗慢性乙型肝炎合并肝纤维化的临床疗效。方法:将105例患者随机分为对照组51例和观察组54例。对照组给予水飞蓟宾葡甲胺片治疗,观察组联合使用苦参素、复方丹参注射液治疗。结果:治疗前两组患者白蛋白(ALB)、总胆红素(TBIL)、总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、透明质酸(HA)、层粘蛋白(LN)、Ⅲ型胶原前肽(PCⅢ)、Ⅳ型胶原(Ⅳ-C)比较,差异无统计学意义(P>0.05)。治疗12周后,观察组ALB显著高于对照组,TBIL、TBA、ALT、AST、HA、LN、PCⅢ、Ⅳ-C显著低于对照组,差异有统计学意义(P<0.05)。观察组有效率显著优于对照组,差异有统计学意义(P<0.05)。结论:苦参素联合复方丹参注射液治疗慢性乙型肝炎合并肝纤维化疗效确切,可以改善患者的肝功能以及肝纤维化。

Objective： To observe the clinical curative effect of kushenin in combination with compound radix salviae miltiorrhizae injection on chronic hepatitis B merged with liver fibrosis. Methods： One hundred and five patients with chronic hepatitis B merged with liver fibrosis were randomly divided into the control group and the observation group,with 51 and 54 cases respectively in each group. The ones in the control group were treated with Silybin Meglumine Tablets,while the ones in the observation group were treated with kushenin in combination with compound radix salviae miltiorrhizae injection. Results： Before the treatment,the differences in ALB,TBIL,TBA,ALT,AST,HA,LN,PCⅢ,and Ⅳ-C of the two groups had no statistical significance（ P〈0. 05）.After 12 weeks＇ treatment,ALB of the observation group was obviously higher than that of the control group,but its TBIL,TBA,ALT,AST,HA,LN,PCⅢ and Ⅳ-C were obviously lower than those of the control group; And the differences between them had statistical significance（ P〈0. 05）. The effective rate of the observation group was obviously better than that of the control group;And the difference between them had statistical significance（ P〈0. 05）. Conclusion： kushenin in combination with compound radix salviae miltiorrhizae injection has remarkable clinical curative effect on chronic hepatitis B merged with liver fibrosis,can improve the patients＇ liver function and liver fibrosis.