黄连素对早期糖尿病肾病危险因素的影响

The Influence of Berberine on Dangerous Factors Causing Early Stage of Diabetic Nephropathy

目的:观察黄连素对早期糖尿病肾病危险因素的影响。方法:选取早期糖尿病肾病患者100例,随机分为试验组和对照组,每组50例。对照组患者进行运动治疗和饮食治疗,试验组患者在对照组的基础上采用黄连素治疗。结果:试验组治疗后BMI、FPG、TC、TG、HOMA-IR、Hb A1C均优于对照组(P<0.05);试验组治疗后BUN、Scr与对照组比较无显著性差异(P>0.05)。结论:黄连素能明显降低早期糖尿病肾病患者的血脂、血糖,改善患者的胰岛素抵抗能力等危险因素。

Objective： To observe the influence of berberine on dangerous factors causing early stage of diabetic nephropathy. Methods： One hundred patients with early stage of diabetic nephropathy were randomly divided into the experiment group and the control group,with 50 cases in each group. The ones in the control group were given movement and diet treatment,while the ones in the experiment group were added berberine based on the treatment of the control group. Results： After the treatment,BMI,FPG,TC,TG,HOMA-IR and Hb A1 C of the experiment group were all better than those of the control group（ P〈0. 05）. After the treatment,in terms of BUN and Scr,there were no obvious significance between the two groups（ P〈0. 05）. Conclusion： Berberine can obviously reduce blood fat and blood sugar of patients with early stage of diabetic nephropathy,and improve dangerous factors,for example,insulin resistance,etc.