失笑散联合辛伐他汀治疗颈动脉斑块临床研究

The Clinical Research into Carotid Artery Plaque Treated with Sudden Smile Powder in Combination with Simvastatin Tablets

目的:观察失笑散联合辛伐他汀治疗颈动脉斑块的临床疗效。方法:将60例患者随机分为对照组和观察组,每组各30例。对照组单纯口服辛伐他汀,观察组在对照组的基础上加用失笑散。记录两组患者同型半胱氨酸Hcy水平、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、年龄之间的差异,分析患者发生颈动脉粥样硬化的危险因子。结果:通过Logistic可知Hcy、TC、HDL-C、LDL-C、年龄均是颈动脉粥样硬化的危险因子。两组患者治疗后Hcy、TC、HDL-C、LDL-C浓度、狭窄率积分均较治疗前改善,且观察组改善幅度大于对照组,差异具有统计学意义(P<0.05)。结论:失笑散联合辛伐他汀能降低颈动脉斑块危险因子浓度,达到改善颈动脉狭窄率、预防脑卒中目的。

Objective： To observe the clinical curative effect of Sudden Smile Powder in combination with simvastatin tablets on carotid artery plaque. Methods： Sixty patients with carotid artery plaque were randomly divided into the control group and the observation group,with 30 cases in each group. The ones in the control group were only treated with simvastatin tablets for oral administration,while the ones in the observation group were added Sudden Smile Powder based on the treatment of the control group. Then the patients＇ Hcy level,TC,HDL-C,LDL-C and the age difference in the two groups were recorded to analyze the dangerous factors leading to carotid atherosclerosis. Results： Through Logistic,it could be said that Hcy level,TC,HDL-C,LDL-C and the age difference were all dangerous factors leading to carotid atherosclerosis. After the treatment,Hcy level,TC,HDL-C,LDL-C density,and restenosis rate score were all improved than before the treatment; And the improved degrees of the observation group were larger than those of the control group. And the differences were statistically significant（ P〈0. 05）. Conclusion： Sudden Smile Powder in combination with simvastatin tablets can reduce the density of dangerous factors leading to carotid artery plaque,improve carotid restenosis rate,and prevent brain stroke.