痰热清联合阿奇霉素治疗小儿支原体肺炎临床研究

The Clinical Research into Mycoplasmal Pneumonia of Children Treated with Tanreqing in Combination with Azithromycin

目的:观察痰热清联合阿奇霉素治疗小儿支原体肺炎的临床疗效。方法:将67例患者随机分为治疗组34例和对照组33例。对照组给予阿奇霉素治疗,治疗组在对照组的基础上联合痰热清。结果:治疗组有效率为94.12%,支原体转阴率为97.06%,均高于对照组,治疗组不良反应发生率为5.88%,显著低于对照组的8.18%,差异均有统计学意义(P<0.05);治疗组肺部啰音消失、止咳、退热及住院时间均短于对照组,CD3+、CD4+、CD4/CD8恢复高于对照组,CD8+低于对照组,差异均有统计学意义(P<0.05)。结论:痰热清联合阿奇霉素治疗小儿支原体肺炎具有显著疗效,可有效促进支原体转阴,缓解患儿临床症状,控制感染,且安全性高。

Objective： To observe the clinical curative effect of Tanreqing（ TRQ） in combination with azithromycin on mycoplasmal pneumonia of children. Methods： Sixty-seven patients with mycoplasmal pneumonia of children were randomly divided into the treatment group and the control group,with 34 and 33 cases respectively in each group. The ones in the control group were treated with azithromycin,while the ones in the treatment group were added TRQ based on the treatment of the control group. Results： The effective rate and the mycoplasmal negative conversion rate of the treatment group were 94. 12% and 97. 06% respectively,which were all higher than those of the control group. The occurrence rate of adverse reactions of the treatment group was 5. 88%,which was much lower than that（ 8. 18%） of the control group. And the difference was statistically significant（ P〈0. 05）. The time for pulmonary rales disappearance,stopping cough,relieving fever and hospitalization of the treatment group was all shorter than that of the control group; Its CD3 ＋,CD4 ＋,CD4 / CD8 recovery was higher than those of the control group; Its CD8 ＋ was lower than that of the control group. And all the differences were statistically significant（ P〈0. 05）. Conclusion： TRQ in combination with azithromycin has remarkable clinical curative effect on mycoplasmal pneumonia of children,can greatly promote mycoplasmal to change towards negative,relieve the diseased children＇s clinical symptoms,control infections and has high safety.