老年急性冠状动脉综合征患者血清尿酸水平与NT-proBNP及GRACE危险评分的相关性分析

Correlation analysis of serum uric acid level with NT-proBNP and GRACE risk score in elderly patients with acute coronary syndrome

目的：探讨老年急性冠状动脉综合征（ACS）患者血清尿酸水平与N末端B型钠尿肽原（NT- proBNP）及GRACE危险评分的相关性。方法143例老年ACS患者按照入院时血清尿酸四分位数分组为：Ⅰ组（尿酸＜278.32μmol/L）、Ⅱ组（尿酸287.33～334.46μmol/L），Ⅲ组（尿酸334.47～386.26μmol/L），Ⅳ组（尿酸＞386.27μmol/L），测定NT- proBNP、心肌肌钙蛋白I（cTnI）及肌酸激酶同工酶（CK- MB），计算GRACE危险评分，对血清尿酸与NT- proBNP、GRACE危险评分进行相关性分析。结果Ⅳ组NT- proBNP [（803.38±235.47）pg/ml]、GRACE危险评分[（138.3±42.5）]、cTnI [（5.49±1.54）μg/L]、CK- MB[（68.37±18.45）μg/L]显著高于Ⅰ组[（326.56±71.30）、（103.4±20.4）、（1.81±0.53）、（42.29±12.30）]、Ⅱ组[（295.5±55.82）、（96.3±18.8）、（1.62±0.45）、（38.29±10.89）]及Ⅲ组[（567.39±125.73）、（126.4±35.4）、（3.67±1.22）、（56.49±13.44）]，Ⅲ组高于Ⅰ组及Ⅱ组（均P＜0.05）；血清尿酸与NT- proBNP、GRACE危险评分呈正相关（r=0.432、0.365，均P＜0.05）。结论老年ACS患者血清尿酸水平与NT- proBNP及GRACE危险评分相关。

Objective To investigate the correlation of serum uric acid level with NT- proBNP and GRACE risk score in elderly patients with acute coronary syndrome （ACS）. Methods 143 elderly patients with ACS were classified by quartile of serum uric acid on admission：group I （uric acid〈278.32μmol/L）, groupⅡ （287.33~334.46μmol/L）, groupⅢ（334.47~386.26μmol/L）, groupⅣ（uric acid〉386.27μmol/L）. NT- proBNP, creatine kinase isoenzyme（CK- MB）, troponin I （cTnI） were measured and GRACE risk score was calculated. The association of serum uric acid with NT- proBNP and GRACE risk score was analyzed. Results NT- proBNP, GRACE risk score, cTnI and CK- MB were significantly higher in group IV [（803.38±235.47）pg/ml,（138.3±42.5）,（5.49±1.54）μg/L,（68.37±18.45）μg/L] than in group I [（326.56±71.30）, （103.4±20.4）, （1.81±0.53）, （42.29±12.30）], grouo II[（295.5±55.82）, （96.3±18.8）, （1.62±0.45）, （38.29±10.89）]and group III[（567.39±125.73）, （126.4±35.4）, （3.67±1.22）, （56.49±13.44）]（al P〈0.05）. These were significantly higher in group III than in groupⅠand Ⅱ （al P〈0.05）;Pearson correlation analysis showed that serum uric acid was positively related to NT-proBNP and GRACE risk score（r=0.432、0.365, P〈0.05）. Conclusion Serum uric acid level is related to NT- proBNP and GRACE risk score in elderly patients with ACS.