Tp-Te间期和Tp-Ted与老年急性心力衰竭患者心血管不良事件的关系

The association of Tp-Te interval and its dispersion with main adverse cardiovascular events in elderly patients with acute heart failure

目的探讨Tp-Te间期及其离散度与老年急性心力衰竭(AHF)患者发生近期心血管不良事件(MACE)的关系。方法 102例老年AHF患者为研究对象,以住院期间是否发生主要MACE分为不良事件组(n=30例)和非事件组(n=72例);比较组间Tp-Te间期和Tp-Te间期离散度(Tp-Ted),左心室射血分数、左心室舒张末期内径(LVEDd)及左心室收缩末期内径(LVESd)、N末端B型脑钠肽原(NT-proBNP)。结果与非事件组比较,不良事件组患者Tp-Te间期和Tp-Ted较大(P<0.05),NT-proBNP偏高(P<0.05),LVEF偏低(P<0.05);Tp-Te间期和Tp-Ted与NT-proBNP、LVEDd呈正相关(均P<0.05),与LVEF呈负相关(均P<0.05);多因素logistic回归分析显示,Tp-Te间期和Tp-Ted与MACE呈独立正相关(均P<0.05)。结论 Tp-Te间期和Tp-Ted增大的老年AHF患者发生MACE的危险性增高。

Objective To investigate the association of Tp- Te interval and its dispersion with main adverse cardiovascular events （MACE） in elderly patients with acute heart failure （AHF）. Methods 102 cases of elderly patients with AHF were enrol ed. Of them, 30 cases had MACE （adverse event group）, 72 had no MACE （non- adverse event group. Tp- Te interval, Tp- Te interval dispersion （Tp- Ted）, left ventricular ejection fraction （LVEF）, left ventricular end diastolic dimension （LVEDd） and end systolic dimension, NT- proBNP were compared between groups. Results Tp- Te interval, Tp- Ted and NT- proBNP were significantly higher and LVEF was significantly lower in adverse event group than non- adverse event group （al P〈0.05）. NT- proBNP and LVEDd were positively and LVEF was negatively correlated with Tp- Te interval and Tp- Ted （al P〈0.05）. Multivariable Logistic regression analysis showed that Tp- Te interval and Tp- Ted were positively correlated with MACE （P〈0.05）. Conclusion The risk of MACE increases in elderly patients with AHF as Tp- Te interval and Tp- Ted increase.