嗜酸性粒细胞增多症患者合并脑梗死的相关危险因素分析

Relative risk factors of cerebral infarction in patients with hypereosinophilic syndrome

目的：探讨嗜酸性粒细胞增多症（HES）合并脑梗死的危险因素。方法采用回顾性病例对照研究的方法，调查了2005年3月至2015年3月期间陕西省人民医院、西安交通大学附属第二医院连续收治住院的HES患者的病历数据和随访资料，分析患者的病程、实验室检查、影像学检查、治疗方法等临床资料，根据是否发生脑梗死进行相关危险因素分析。结果120例HES患者中有8例患者出现脑梗死，发病率为6.7%，其中男性6例，女性2例。实验室生化指标中肌酸激酶同工酶及肌钙蛋白T在脑梗死患者中较未发生脑梗死的患者明显升高，差异具有统计学意义（P＜0.05）。结论 HES患者脑梗死风险较高，其脑梗死发病机制可能与HES所致心内膜和心肌损伤、坏死，血栓形成，栓子脱落发生栓塞有关。

Objective To investigate the relative risk factors of cerebral infarction in the patients with hypereosinophilic syndrome （HES）. Methods A retrospective case-control study was carried out on all the consecutive in-patients diagnosed with eosinophilia in the Shaanxi Provincial People’s Hospital and the Second Affiliated Hospital of Xi’an Jiaotong University from March 2005 to March 2015. Their clinical data and follow-up information were collected. Disease course, laboratory results, radiological results, and treatment recordings were analyzed for their correlation with the occurrence of cerebral infarction. Results A total of 120 HES patients were enrolled in this study, and 8 of them （6 males and 2 females） suffered from acute cerebral infarction, with an incidence of 6.7%. Laboratory examination indicated that the serum levels of creatine kinase isoenzyme and troponin T were obviously higher in those with acute cerebral infarction than those without （P〈0.05）. Conclusion HES patients are at high risk of cerebral infarction, which might be due to the impairment and necrosis of endocardium and myocardium, thrombogenesis, and embolism.