哺乳动物雷帕霉素靶蛋白信号通路与眼科疾病相关性的研究进展

Advance in research on the relationship between mammalian target of rapamycin signaling pathway and ophthalmic diseases

哺乳动物雷帕霉素靶蛋白（mTOR）是一种高度进化保守的蛋白激酶，控制细胞生长、生长因子和细胞能量的形成，参与营养、新陈代谢及老化过程，近年发现mTOR信号通路与细胞生长、调控蛋白质合成代谢密切相关，已成为肿瘤形成、代谢紊乱、神经系统疾病和炎症等疾病的重要通路。就mTOR及通路介导的眼科疾病进行综述。

Mammalian target of rapamycin （roTOR） is a highly evolutionary conserved protein kinase and plays a critical role in the regulation of cell growth, growth factors and cell energy, and thus contributes to the formation of nutrition, metabolism and aging processes. Recent studies found that mTOR signaling pathway is associated with cell cycle, protein synthesis and metabolism, and it is an important pathway of diseases such as development of tumor,metabolic disorders,nervous system disease and inflammation. The relationship between roTOR signaling pathway and ophthalmic diseases was reviewed in this article.