摘要
目的探讨化生性乳腺癌组织中Snail和上皮性钙黏附素(E-cad)的表达水平及其与临床病理特征的关系。方法采用免疫组化SP法检测58例化生性乳腺癌组织中Snail和E-cad的表达,并收集相应病例的临床病理资料,分析Snail、E-cad表达与化生性乳腺癌临床病理特征的关系及两蛋白的相关性,同时根据随访资料分析两者表达与复发转移的关系。结果在化生性乳腺癌中,Snail和E-cad的阳性表达率分别为77.6%(45/58)和48.3%(28/58)。Snail的表达与临床分期、淋巴结转移和ER表达有关(P<0.05),而E-cad表达与组织学分级、淋巴结转移有关(P<0.05),两者与年龄、HER-2表达、病理类型、肿瘤大小及月经状态均无关(P>0.05)。Snail与E-cad的表达呈负相关(r=-0.308,P=0.019),且均与化生性乳腺癌复发转移有关(P<0.05)。结论 Snail和E-cad联合检测可判断化生性乳腺癌的恶性程度和侵袭能力,且与复发转移有关,两者有望作为化生性乳腺癌治疗的分子靶点。
Objective To investigate the expression of Snail and E-cadherin（ E-cad） in metaplastic breast cancer（ MBC）tissues as well as their relationship with clinicopathological parameters. Methods The expression of Snail and E-cad in 58 cases of MBC were detected by immunohistochemical SP method. The corresponding clinical data were collected and then the relationship of Snail,E-cad expression and the pathological parameters of MBC were analyzed. The relationship between the Snail,E-cad expression and recurrence / metastasis were analyzed according to the follow-up data. Results In these 58 MBC patients,Snail was expressed in45 cases（ 77. 6%） and E-cad was expressed in 28 cases（ 48. 3%）. The expression of Snail was associated with clinical stage,lymph node metastasis and ER expression（ P 0. 05）. The expression of E-cad was associated with histological grade and lymph node metastasis（ P 0. 05）. The two proteins had no relationchip with age,tumor size,menopausal status,HER-2 expression and pathological types（ P 0. 05）. The expression of Snail and E-cadherin had a negative association（ r =- 0. 308,P = 0. 019）. In MBC,both of them had relationship with local recurrence and distant metastasis（ P 0. 05）. Conclusion Snail and E-cadherin may have the ability to recognize the tent of malignancy and invasion of MBC,which may be potential treatment target in MBC.
出处
《临床肿瘤学杂志》
CAS
2015年第9期799-803,共5页
Chinese Clinical Oncology
