冠心病患者尿微量白蛋白水平与冠状动脉病变程度的相关性研究

Correlation Study between Plasma Levels of Microalbuminuria and the Degree of Coronary Artery Lesions for Coronary Heart Disease

目的分析尿微量白蛋白(MAU)水平与冠心病(CHD)患者冠状动脉血管病变程度的相关性。方法收集2009年3月至2013年11月在我科住院的CHD患者967例,行冠状动脉造影(CAG)检查前检测MAU水平,对比分析术前MAU水平与术后CAG结果。结果 1CHD患者MAU水平(46.91±9.31)mg/L明显高于非CHD患者(17.61±6.71)mg/L,差异有统计学意义(P<0.05),MAU≥20mg/L的CHD患者为454例(80.6%)明显高于非CHD患者56例(13.9%),差异有统计学意义(P<0.05);2在CHD患者中随着冠状动脉病变支数的增加,MAU水平升高(P<0.05),MAU≥20mg/L的CHD患者中单支病变为130例(68.7%)、两支病变为110例(74.8%)、三支病变为215例(80.8%),组间比较差异有统计学意义(P<0.05)。结论 CHD患者MAU水平升高与冠状动脉血管病变程度具有一定的相关性,可作为反映冠状动脉血管病变程度的临床预测指标。

Objective To explore the correlation between plasma levels of Microalbuminuria and the degree of coronary artery lesions. Methods From March 2009 to November 2013, 967 cases were collected in our department. We analyzed MAU levels before surgery and the CAG results. Results ①In the aspects of MAU level, CHD cases（46. 91 ± 9. 31mg/L）was signifi-cantly higher than non CHD cases（P〈0. 05）, 454（80. 6%）cases with CHD was significantly higher than 56（13. 9%）cases with non CHD for MAU≥20mg/L（P〈0. 05）;②The numbers of coronary artery lesion were increased with the higher level of MAU （P〈0. 05）;for CHD with MAU≥20mg/L, 130 （68. 7%）cases were single vascular disease, 110（74. 8%）cases were two vas-cular disease, 215（80. 8%）cases were three vascular disease, the difference was statistically significant among the three groups （P〈0. 05）. Conclusions Microalbuminuria is good forecast indexes for the degree of coronary artery vascular lesions.