缺血性脑卒中急性期hs-CRP水平与预后关系的研究

Relationship between hs-CRP Level in Acute Stage and Proghosis of Ischewic Stroke

目的 了解缺血性脑卒中急性期高敏C反应蛋白（ hs-CRP）水平的变化特征,探讨其与预后的关系. 方法前瞻性连续登记2012年9月1日至2014年8月31日我科收治、发病时间≤24h的缺血性脑卒中患者,于入院时或次晨测量血浆hs-CRP水平;收集可能影响hs-CRP和临床结局相关的因素;随访住院期间及发病后3个月末患者的死亡和残疾情况. 结果 本研究共纳入245例缺血性脑卒中急性期患者,入院时hs-CRP为0. 15~40. 56 mg/L,中位值5. 0mg/L,四分位间距2. 0～10. 0mg/L;入院时hs-CRP＆gt;3mg/L是患者住院期间死亡、3个月死亡/残疾独立危险因素,与hs-CRP≤3mg/L患者相比,死亡风险分别增加了1. 578倍、1. 266倍. 结论 入院时hs-CRP是缺血脑卒中住院期间死亡、3个月死亡和残疾独立影响因素.

Objective In the study, we investigated high sensitivity C-reactive protein and clinical characteristics in pa-tients with acute ischemic stroke and explored the association between high sensitivity C-reactive protein and outcomes in acute is-chemic stroke. Methods Prospectively registered consecutive cases of acute ischemic stroke at the neurology department of Wen-jiang People＆#39;s Hospital from September. 01, 2012 to August. 31, 2014. The patients with acute ischemic stroke within 24 hours of symptom onset were included. The level of serum high sensitivity C-reactive protein on admission or the next morning was meas-ured. Other relevant factors influencing level of high sensitivity C-reactive protein and ischemic stroke outcomes were also collect-ed, and outcomes including death or disability were followed up during hospital and at the end of 3 month. Results 245 patients with acute ischemic stroke were involved, the level of high sensitivity C-reactive protein was from 0. 15 mg/L to 40. 56mg/L, the median was 5. 0mg/L, and quartile was 2. 0~10. 0mg/L. hs-CRP＆gt;3mg/L, it became an independent risk factor for death or dis-ability at the end of 3 month. Compared to the lower concentration, which was less than 3 mg/L, the risk of death for these pa-tients was increased by1. 578 and 1. 266, respectively. Conclusion The high sensitivity C-reactive protein on admission was the independent predictive for death/disability at the end of 3 month in acute ischemic stroke.