VEGF对良恶性心包积液的鉴别诊断价值

The value of VEGF in the diagnosis of pericardial effusion

目的探讨VEGF在心包积液病因鉴别诊断中的临床应用价值。方法采用ELISA法,检测34例恶性心包积液与25例非恶性心包积液中VEGF水平,比较良、恶性心包积液中VEGF水平差异。结果恶性心包积液中VEGF水平明显高于非恶性心包积液,当VEGF>1908pg/ml,对恶性心包积液的诊断敏感性及特异性为88%和83.3%。结论恶性心包积液中VEGF水平明显增高,VEGF可作为良恶性心包积液的鉴别诊断的标志物。

Objective To explore the clinical value of VEGF in the differential diagnosis of pericardial effusion.Methods Using an enzyme-linked immunosorbent assay,we assessed pericardial VEGF levels in patients with malignant pericardial effusion（n=34）,in patients with nonmalignant pericardial effusion（n=25）.Results VEGF pericardial levels in malignant pericardial effusion were significantly higher compared with VEGF in nonmalignant effusion.Pericardial VEGF levels≥1 908pg/ml had88% sensitivity and 83.3%specificity for the recognition of malignant pericardial effusion in patients with malignant pericardial effusion.Conclusion VEGF levels were significantly higher in malignant pericardial effusion.VEGF in pericardial effusion offers potential as a diagnostic tool to discriminate malignant from benign effusions.