弥漫大B细胞淋巴瘤Ki-67表达与18F-FDG摄取程度相关性研究及其临床意义

Correlation and clinical signification between the expression of Ki-67 and 18F-FDG uptake level on DLBCL

目的探讨弥漫大B细胞淋巴瘤(Diffuse large B cell lymphoma,DLBCL)Ki-67表达与PET/CT显像18F-FDG摄取程度有无相关性及其临床意义。方法 68例首诊初治弥漫大B细胞淋巴瘤患者,所有患者均经病理及免疫组化结果确诊,治疗前均常规行18F-FDG PET/CT扫描,对其影像资料及结果进行回顾性分析。结果 DLBCL患者病灶18F-FDG平均摄取值(SUVave)与Ki-67呈显著正相关,相关系数r为0.891,P<0.001。DLBCL患者Ki-67表达水平与肿瘤分期、最大肿瘤直径及血LDH水平有统计学差异,与其他临床因素之间无统计学差异。结论 Ki-67与PET/CT在反映DLBCL患者细胞增殖情况及病灶的侵袭程度等方面有着紧密的联系。

Objective To discuss the correlation and clinical signification between the expression of Ki-67 and 18F-FDG uptake level on Diffuse large B cell lymphoma（DLBCL）.Methods The imaging materials and results of 68 DLBCL patients were retrospectively analyzed,all the patients were diagnosed by the pathology and immunohistochemistry,before the treatment all the patients had been examined by PET/CT routinely.Results The 18F-FDG average standard uptake value of DLBCL patients is positively correlated with Ki-67,the correlation coefficient r is 0.891,P0.001.There was a statistical difference between Ki-67 expression level and tumor staging,largest tumor diameter,blood LDH level on DLBCL patients,and there was no statistical difference with other clinical factors.Conclusion There is a close relationship between Ki-67 and PET/CT in reflecting cell proliferation and invasion of the lesions on DLBCL patients.